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Interaction of Val66Met Brain-Derived Neurotrophic Factor and 5-HTTLPR Serotonin Transporter Gene Polymorphisms with Lifetime Prevalence of Post-Traumatic Stress Disorder in Primary Care Patients.
Genes (Basel)
October 2024
Programa de Neurociencia, Psiquiatría y Salud Mental, NEPSAM (http://nepsam.udec.cl), Universidad de Concepción, Barrio Universitario s/n, Casilla 160-C, Concepción 4070386, Chile.
Post-traumatic stress disorder (PTSD) is a complex condition influenced by both genetic and environmental factors. This longitudinal study aimed to explore the connection between two specific genetic polymorphisms, Val66Met and 5-HTTLPR, and the lifetime prevalence of PTSD in patients from primary care settings. We also examined the role of sociodemographic and psychosocial factors to provide a more comprehensive view of PTSD risk.
View Article and Find Full Text PDFPain Candidate Genes 5-HTTLPR and COMT Affect Anxiety and Mood in Japanese Ballet Dancers: A Cross-Sectional and Longitudinal Study.
Sports (Basel)
October 2024
Department of Sports Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki 216-8511, Japan.
The balance of mental, physical, and technical aspects is essential in improving ballet performance. Ballet dancers' emotional and behavioral characteristics vary, even under identical stress conditions. This study aimed to investigate the association between the pain candidate genes 5-HTTLPR and COMT and anxiety in Japanese ballet dancers.
View Article and Find Full Text PDFThe Association between Post-Traumatic Stress Disorder, 5HTTLPR, and the Role of Ethnicity: A Meta-Analysis.
Genes (Basel)
September 2024
Developmental and Educational Dynamics Research Center (CRIdee), Università Cattolica del Sacro Cuore, 20123 Milan, Italy.
Background/objectives: The current meta-analysis looks at the effect of ethnicity on the connection between 5-HTTLPR SNPs and PTSD patients in all published genetic association studies.
Techniques: In accordance with PRISMA principles, the literature was searched in PubMed, Scopus, and ScienceDirect. A consistent method was followed by two reviewers who independently chose publications for inclusion and extracted data.
Serotonin transporter 5-HTTLPR polymorphism and escitalopram treatment response in patients with major depressive disorder.
BMC Psychiatry
October 2024
2nd Department of Psychiatry, Faculty of Medicine, Pavol Jozef Šafárik University, and Louis Pasteur University Hospital, Rastislavova 43, Košice, 04190, Slovakia.
Background: There is no doubt that genetic factors have the potential to predict the therapeutic outcomes of antidepressants in patients with major depressive disorder (MDD). This study investigated the association between genetic variants involved in serotonin signaling and brain-derived neurotrophic factor (BDNF) with the response to escitalopram treatment in patients with MDD. We focused on examining the influence of 5-HTTLPR (ins/del), HTR2A rs9316233, BDNF rs962369, CYP2C19 and CYP2D6 on the clinical response to escitalopram.
View Article and Find Full Text PDFGenetic polymorphisms and their association with neurobiological and psychological factors in anorexia nervosa: a systematic review.
Front Psychol
June 2024
Department of Human Nutrition, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.
Background And Aims: Anorexia nervosa (AN) is a complex neuropsychiatric disorder. This systematic review synthesizes evidence from diverse studies to assess and investigate the association between gene polymorphisms and psychological and neurobiological factors in patients with AN.
Methods: A systematic search across PubMed, PsycINFO, Scopus, and Web of Science databases, along with manual searching, was conducted.
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