AI Article Synopsis
- Pseudoangiomatous stromal hyperplasia (PASH) is a benign breast lesion that can be felt as a lump or found accidentally during biopsies.
- A study of 79 cases from Loyola University Medical Center revealed that most patients were female, with many presenting symptoms from a palpable mass, while others had incidental findings.
- The majority showed classic PASH characteristics, and some had associated benign or atypical epithelial lesions, leading to a recommendation for thorough biopsy analysis and careful follow-up.
Article Abstract
Background: Pseudoangiomatous stromal hyperplasia (PASH) of the breast is a benign lesion that can present as a palpable nodule or as an incidental finding in breast biopsies.
Design: The study comprised 79 cases diagnosed at Loyola University Medical Center from 2002 to 2009. The pathology slides were reviewed to document the distribution, type, and association with preneoplastic or neoplastic epithelial lesions. Z-test for independent proportions is used for analysis.
Results: A total of 76 patients were female and 3 were male. In all, 59.8% of patients presented with a breast mass and in 40.2% the lesion was an incidental finding. Classical PASH morphology was seen in 97.6% and proliferative PASH in 2.4%. Associated epithelial lesions were benign proliferative changes in 60.4%, atypical ductal and atypical lobular hyperplasia in 25.6% and infiltrating carcinoma in 11% of cases.
Conclusions: Based on these results, extensive sampling of biopsy specimen with PASH and appropriate clinical and radiologic follow-up is recommended.
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| http://dx.doi.org/10.1177/1066896911418643 | DOI Listing |
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