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Deficiency of adenosine deaminase 2 (DADA2) with recurrent ischemic stroke, fever and cutaneous changes: A case report.
Neurol Sci
January 2025
Department of Neurology, Peking Union Medical College Hospital, 100730, Beijing, China.
UVB Induces Sympathetic Nervous System Activation and Norepinephrine Secretion to Regulate The Skin Color of Mice Through the β2-AR/AP-1 Pathway in Epidermal Keratinocytes.
Inflammation
January 2025
Department of Dermatology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), NO. 1 Jiazi Road, Lunjiao, Shunde District, Foshan City, 528308, Guangdong, China.
The aim of this study was to investigate how ultraviolet B (UVB) light regulates AP-1 expression via the β2-adrenergic receptor (β2-AR) in epidermal keratinocytes, which in turn regulates melanin synthesis in melanocytes, thereby modulating downstream melanin production in skin hair follicles and altering mouse skin color. We established a UV-irradiated mouse model to investigate the effects of UV radiation on changes in skin color. By measuring changes in the expression of genes related to cutaneous sympathetic nerves, norepinephrine synthesis and melanin synthesis, we investigated the relationship between β2-AR expression and cutaneous melanogenesis and determined the localization of β2-AR in cells.
View Article and Find Full Text PDFBlue Nevus-Like Metastatic Melanoma in a Patient With Primary Lentigo Maligna Melanoma.
J Cutan Pathol
January 2025
Stritch School of Medicine, Loyola University, Maywood, Illinois, USA.
Metastatic melanoma with unusual histopathology can be diagnostically challenging. One exceptionally rare cutaneous manifestation of metastases is blue-nevus-like metastatic melanoma (BNLMM). A 74-year-old male presented with a blue-gray lesion on his left helix in the same anatomical region of a previously resected lentigo maligna.
View Article and Find Full Text PDFVitiligo and the microbiome of the gut and skin: a systematic review.
Arch Dermatol Res
January 2025
Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York City, New York, 10029, USA.
Vitiligo is a chronic autoimmune skin condition characterized by depigmentation due to the destruction of melanocytes. Recent research has identified potential links between vitiligo and alterations in both the gut and skin microbiomes. This systematic review aims to explore these microbiome changes and their potential role in the onset and progression of vitiligo.
View Article and Find Full Text PDFGlobal, regional, and national burden of cutaneous malignant melanoma from 1990 to 2021 and prediction to 2045.
Front Oncol
December 2024
Center of Burns and Plastic Surgery and Dermatology, The 924th Hospital of Joint Logistics Support Force of the People's Liberation Army (PLA), Guilin, China.
Background: Cutaneous Malignant Melanoma (CMM) is a significant global health challenge. Understanding regional differences in CMM prevalence and trends is crucial for developing targeted strategies. To address this, we analyzed epidemiological patterns and investigated risk factors for CMM-related mortality.
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