The ankles play an important role in human balance. In most studies investigating balance control the contribution of the left and right leg is not separated. However, in certain pathologies such as stroke and Parkinson's disease, balance control can be asymmetric. Here, a bilateral ankle perturbator (BAP) is presented, which applies support surface rotations to both ankles independently. The device consists of two small foot-size support surfaces, which are independently actuated. The BAP device can operate in either angle or torque control mode. The device is able to apply support surface rotations up to 8.6° with a bandwidth of 42 Hz. Additionally the platforms can be replaced by 6-DoF force plates to measure the center of pressure underneath each foot. With the optional force plates the bandwidth decreases to 16 Hz as a result of the additional weight. Two possible applications of the device to investigate human balance control are demonstrated: ankle stiffness by applying minimum jerk profiles and sensory reweighting of the proprioceptive information. In conclusion, we developed a bilateral ankle perturbator which is able to apply support surface rotations to both ankles independently. The major application of the device will be to investigate the contribution of both ankles to human balance control, and the interactions in balance control between both legs.
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http://dx.doi.org/10.1109/TNSRE.2011.2163644 | DOI Listing |
J Int Neuropsychol Soc
January 2025
Department of Psychiatry, Ankara University, Ankara, Turkey.
Objectives: This study compared cognitive flexibility (CF) and emotion recognition (ER) in adolescents with eating disorders (ED) to a healthy group.
Methods: Forty healthy individuals aged 12-18 years with no psychiatric diagnosis and 46 patients diagnosed with anorexia nervosa (AN), bulimia nervosa (BN), or binge eating disorder (BED) according to DSM-5 criteria participated. CF was assessed using the Cognitive Flexibility Scale (CFS), Stroop Test, and Berg Card Sorting Test (BCST), while ER was evaluated using the test of perception of affect via nonverbal cues.
BMC Gastroenterol
January 2025
Department of Pediatrics, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710061, China.
Background: The increased apoptosis of bile duct epithelial cells (BECs) due to some damage factors is considered the initiating factor in the occurrence and progression of biliary atresia (BA). Vitamin D receptor (VDR) is thought to play a crucial role in maintaining the intrinsic immune balance and integrity of bile duct epithelial cells (BECs). To investigate the role of VDRs in the pathogenesis and progression of BA using in vitro and in vivo models.
View Article and Find Full Text PDFPhysiol Behav
January 2025
Dipartimento di Psicologia Dinamica, Clinica e Salute, Sapienza Università di Roma.
Until now, it has been challenging to examine what are the causes of the cognitive decline associated with hypertension and to understand the predictive variables that indicate the development of cognitive impairment in people with hypertension. This work is aimed to understand the interplay between heart rate variability and blood pressure and whether their combination can predict cognitive performance. This cross-sectional observational study involved patients with fifty-two adults with essential hypertension and a control group of 41 healthy adults without hypertension.
View Article and Find Full Text PDFJ Environ Manage
January 2025
Key Laboratory of Water Cycle & Related Land Surface Processes, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, 100101, China; University of Chinese Academy of Sciences, Beijing, 101407, China.
Rainwater harvesting systems (RHS) are extensively executed to manage stormwater control and water shortage issues in cities. However, the influences of rainfall characteristics on the performances of RHS are still not deeply explored. In this research, a methodology framework is developed to explore the influences of rainfall characteristics on stormwater control and water saving performances of RHS, by using daily precipitation data during 1968-2017 at 30 stations across the Beijing region as a testbed.
View Article and Find Full Text PDFNat Rev Mol Cell Biol
January 2025
Howard Hughes Medical Institute, Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY, USA.
Adult stem cells balance self-renewal and differentiation to build, maintain and repair tissues. The role of signalling pathways and transcriptional networks in controlling stem cell function has been extensively studied, but there is increasing appreciation that mechanical forces also have a crucial regulatory role. Mechanical forces, signalling pathways and transcriptional networks must be coordinated across diverse length and timescales to maintain tissue homeostasis and function.
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