Being the most critical signaling molecule in the Wnt pathway, the Wnt/β-catenin signaling pathway plays an important role in the maintenance of the cell proliferation and clone formation of lung cancer stem cells. Since it is closely related to the WNT pathway, the proliferation of lung cancer stem cells can be restrained by blocking the WNT pathway or influencing its key protein. Such method provides a new method for the treatment of lung cancer. By summarizing the state of-the-art research of lung cancer stem cells and the Wnt pathway from 2005 to 2010, their relationship is investigated.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999629 | PMC |
| http://dx.doi.org/10.3779/j.issn.1009-3419.2011.08.11 | DOI Listing |
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