Condensin I is important for chromosome organization and segregation in mitosis. We previously showed that condensin I also interacts with PARP1 in response to DNA damage and plays a role in single-strand break repair. However, whether condensin I physically associates with DNA damage sites and how PARP1 may contribute to this process were unclear. We found that condensin I is preferentially recruited to DNA damage sites enriched for base damage. This process is dictated by PARP1 through its interaction with the chromosome-targeting domain of the hCAP-D2 subunit of condensin I.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155556 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0023548 | PLOS |
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