Objective: To investigate possible neuroprotective effects of dietary supplementation of fish oil in brain ischemia-reperfusion (I/R).
Methods: This investigation took place in the Experimental Research Unit, Firat University, Elazig, Turkey, from January-February 2006. The study was carried out on 12 male Wistar rats; divided into 2 groups: I/R (control) and I/R + omega-3 essential fatty acids (EFA) (experiment). The rats in the I/R group received only ordinary rat food before middle cerebral artery (MCA) occlusion. The I/R + omega-3 EFA group received omega-3 fatty acid daily via intragastric gavage (300 mg/kg Marincap capsule) with normal food before MCA occlusion for 30 days. Structural alterations in the brain tissues were semi-quantitatively analyzed (0: absent, +: slight, ++: moderate, +++: severe).
Results: There was evident severe (+++) edema, vacuolization, and eosinophilic degeneration in the I/R group, while only slight (+) edema and eosinophilic degeneration in the I/R + omega-3 EFA group in which no vacuolization was determined. These findings are consistent with the available studies in this field.
Conclusion: Results from this study indicate the beneficial effects of omega-3 EFA supplementation in prevention of I/R - induced damage in rats.
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Article Synopsis
- After a heart attack, a treatment called coronary angioplasty can cause some damage to the heart, known as ischemia-reperfusion (I/R) injury.
- Omega-3 fatty acids (PUFAs) can help protect the heart, but scientists found a way to make them work better using a special compound called poly-l-glutamic acid (PGA).
- By combining PGA with a specific omega-3 fatty acid (diDHA), it helps protect heart cells from damage and could lead to better treatments for patients after heart surgeries.
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