Purpose Of Review: This review discusses the recent data about the pathogenesis of Chagas disease, tolerance of drugs, and follow-up of patients impacting the treatment of Chagas disease in immunocompetent and immunocompromised patients.
Recent Findings: The role of the parasite to promote direct or indirect organ damage in the chronic phase of the disease as well as the usefulness of antiparasitic treatment to slow or prevent the deterioration of cardiac function and the aggravation of Chagasic cardiomyopathy lead to an extension of the indications of treatment. Tolerance is poor for the two drugs, benznidazole and nifurtimox. The rates of adverse events and treatment discontinuation before 60 days are higher with nifurtimox. PCR, and in the near future immunologic tests, might allow assessment of the early success or failure of the antiparasitic treatment.
Summary: Assessment of alternative drugs, such as posaconazole, and of new strategies of treatment (combination of two antiparasitic drugs, association of antiparasitic and immunomodulatory drugs, and re-treatment), and follow-up are a global health priority.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/QCO.0b013e32834a667f | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of 12-week dietary nitrate supplementation on carotid arterial stiffness in postmenopausal females.
Am J Physiol Heart Circ Physiol
March 2025
Multidisciplinary Center UFRJ-Macaé, Federal University of Rio de Janeiro, Macaé, Rio de Janeiro, Brazil.
Menopause is associated with reduced nitric oxide (NO) bioavailability, a key contributor to increased arterial stiffness and, consequently, greater risk of cardiovascular disease (CVD)-related mortality in postmenopausal females. Even though dietary nitrate has been shown to increase NO bioavailability in postmenopausal females acutely, previous studies showed no impact of dietary nitrate supplementation on arterial stiffness in postmenopausal females. Their findings were likely limited by the acute and/or short-term design.
View Article and Find Full Text PDFHospesneotomae n. gen. of the Triatomini tribe presents a turnaround in the taxonomy of the Triatoma protracta species complex.
Sci Rep
March 2025
School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, Brazil.
The Triatominae are of relevant public health importance because they include hematophagous species which are proven or potential vectors of Chagas disease. Currently, eighteen genera are considered valid in this subfamily. Through a comprehensive and integrative study, the description of a new genus of Triatomine, the nineteenth of the subfamily, is presented.
View Article and Find Full Text PDFPrevalent zoonoses in Sao Paulo State, Brazil: the role of bats and molecular diagnosis.
Rev Inst Med Trop Sao Paulo
March 2025
Universidade Estadual Paulista, Departamento de Produção Animal e Medicina Veterinária Preventiva, Botucatu, São Paulo, Brazil.
This review explores the landscape of prevalent zoonotic diseases in Sao Paulo State, Brazil, focusing on the role of bats as reservoirs and the application of molecular biology in the diagnosis. The zoonoses covered include visceral and cutaneous leishmaniasis, Chagas disease, toxoplasmosis, bartonellosis, Q fever, Brazilian spotted fever, and leptospirosis. Molecular techniques can improve public health responses by accurately identifying pathogens and tracking their transmission dynamics in populations, thus enhancing early detection, characterization of strains, and monitoring of disease outbreaks.
View Article and Find Full Text PDFPharmacokinetics of two pharmaceutical presentations of benznidazole in adult Trypanosoma cruzi infected population.
Mem Inst Oswaldo Cruz
March 2025
Administración Nacional de Laboratorios e Institutos de Salud Dr Carlos G Malbrán, Instituto Nacional de Parasitología Fatala Chaben, Ciudad Autónoma de Buenos Aires, Argentina.
Background: Benznidazole (BNZ) is the primary treatment for Chagas disease. While pharmacokinetic studies of BNZ began in the 1970s, its metabolism and excretion are not fully understood. Alternatives like Benznidazol Lafepe® and Abarax® have replaced the original Radanil®.
View Article and Find Full Text PDF[Influence of primary care coverage and home visits on the detection of tuberculosis cases in the municipality of Rio de Janeiro, Brazil, 2014-2022].
Cad Saude Publica
March 2025
Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.
Despite efforts to reduce its incidence, tuberculosis (TB) control still challenges the municipality of Rio de Janeiro, Brazil. This study aimed to analyze the temporal trend and effect of TB surveillance and access to health services on the detection of TB cases in Rio de Janeiro (2014-2022). This ecological study evaluated all cases of TB that were reported monthly in residents of Rio de Janeiro.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!