The abortive properties and the clinical and pathological features of poisoning by the pods of Stryphnodendron fissuratum were studied in 8 pregnant goats. Two goats that ingested 3.25 g/kg body weight daily doses for 2 days, and 2 that ingested 2.5 g/kg daily doses for 3 days showed digestive clinical signs and aborted, but the animals that ingested 3 daily doses of 2.5 g/kg died. Lesions of the digestive system and liver were observed at necropsy. Two goats that ingested a single dose of 5.5 g/kg showed mild clinical signs and recovered without abortion. Another 2 goats that ingested single doses of 5 g/kg showed no clinical signs. These results demonstrate that Stryphnodendron fisuratum pods cause digestive disorders, liver disease, abortion and death.

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http://dx.doi.org/10.1016/j.toxicon.2011.07.017DOI Listing

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