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Mapping Bullous Emphysema With Lung Ultrasound: A Prospective Multicentre Study.
Respirology
March 2025
Department of Pneumology, Thoracic Oncology and Respiratory Intensive Care Unit, Rouen, France.
Background And Objectives: Lung ultrasound holds high diagnostic performance for pleural diseases, notably pneumothorax. Bullous emphysema is a potential differential diagnosis of pneumothorax on ultrasound, but its precise semiology is poorly known. This study aimed to delineate the sonographic presentation of bullous emphysema and assess the diagnostic performance of common ultrasound features in identifying bullae.
View Article and Find Full Text PDFRelapsing polychondritis: tracheobronchial involvement and differential diagnoses.
J Thorac Dis
January 2025
Pulmonology Department, Reference Center for Rare Pulmonary Diseases, Hôpital Avicenne, Assistance Publique - Hôpitaux de Paris - Hôpitaux Universitaires de Paris Seine-Saint-Denis, Bobigny, France.
This review is describing the diagnostic and therapeutic approach to tracheobronchial involvement in relapsing polychondritis (RP), with a focus on differential diagnoses of inflammatory origin. RP is a systemic auto-immune disease that mainly affects cartilage structures, progressing through inflammatory flare-ups between phases of remission and ultimately leading to deformation of the involved cartilages. Besides the damage of auricular or nasal cartilage, tracheobronchial and cardiac involvement are the most severe, and can seriously alter the prognosis.
View Article and Find Full Text PDFAn Adverse Double-Hit by Pembrolizumab: A Case Report of Bullous Pemphigoid and Pneumonitis.
J Med Cases
February 2025
Division of Infectious Diseases, Department of Internal Medicine, University of Patras Medical School, Patras, Greece.
Immune checkpoint inhibitors like pembrolizumab represent a modern approach to the management of various malignancies, including non-small cell lung cancer. The therapeutic activity of immunotherapy is exerted by the activation of immune cells against the tumor cells. However, systemic activation of the immune system can lead to the development of autoimmune complications known as immune-related adverse events.
View Article and Find Full Text PDFSintilimab-induced photodistributed bullous pemphigoid: A case report.
Medicine (Baltimore)
February 2025
Department of Dermatology, Hangzhou Third People's Hospital, Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.
Rationale: Immune-checkpoint inhibitors have emerged as a frontline treatment for a growing list of malignancies. Immunotherapy-induced bullous pemphigoid (BP) is a rare dermatological immune-related adverse event of immune-checkpoint inhibitor therapy immune-checkpoint inhibitor therapy. We report a case of immunotherapy-associated BP, with lesions presenting in a photodistribution.
View Article and Find Full Text PDFSevere bullous emphysema: exploring risk factors and the importance of radiography.
Radiol Case Rep
April 2025
Department of Medicine, West Virginia University, 1 Medical Center Drive, Morgantown, WV 26506, USA.
Bullous emphysema, a subtype of emphysema, is characterized by the irreversible enlargement of air-filled airways greater than 1cm in size. Often time, practitioners focus on smoking duration in pack years, and smoking frequency, rather than smoking onset, when assessing risk for development of bullous emphysema. Distinct radiographic findings on CT imaging can differentiate bullae from other lung pathologies, including lung cysts.
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