AI Article Synopsis
- The study found that ursolic acid activates PPAR-α, which is important for regulating lipid metabolism.
- Ursolic acid doesn't bind directly to PPAR-α but enhances its ability to interact with DNA, influencing gene expression.
- This compound helps lower triglyceride and cholesterol levels in liver cells, indicating its potential as a PPAR-α agonist.
Article Abstract
In this study, we confirmed that ursolic acid, a plant triterpenoid, activates peroxisome proliferator-activated receptor (PPAR)-α in vitro. Surface plasmon resonance and time-resolved fluorescence resonance energy transfer analyses do not show direct binding of ursolic acid to the ligand-binding domain of PPAR-α; however, ursolic acid enhances the binding of PPAR-α to the peroxisome proliferator response element in PPAR-α-responsive genes, alters the expression of key genes in lipid metabolism, significantly reducing intracellular triglyceride and cholesterol concentrations in hepatocytes. Thus, ursolic acid is a PPAR-α agonist that regulates the expression of lipid metabolism genes, but it is not a direct ligand of PPAR-α.
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| http://dx.doi.org/10.1016/j.bmcl.2011.07.095 | DOI Listing |
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