The present study evaluated the anticomplement effects from isolated compounds of Sorghum bicolor in classical pathway complement system. Using column chromatograph, three compounds; Sorgoleone-362 (1), Sorgoleone-360 (2) and Sorgoleone-386 (3) were isolated and evaluated for in vitro anticomplement activity. Sorgoleone-386 showed inhibitory activity against complement system with 50% inhibitory concentrations (IC(50)) values of 148.3μg/ml. This is the first report of anticomplement activity of isolated compounds from Sorghum bicolor.
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| http://dx.doi.org/10.3109/08923973.2011.602690 | DOI Listing |
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