The paper presents the results of biopsy and curettage specimens from 92 patients with infertility. Histological and immunohistological (steroid receptors, Ki67, P27, and cyclin E) methods and scanning electron microscopy have been used. The substantial immunohistochemical (IHC) changes found in the endometrial implantation window in infertility are associated with the spectrum of the detected pathology. No clear correlations between the expression of IHC markers and the concentrations of serum hormones, which are characteristic of the normal menstrual cycle, may suggest that there is an imbalance of steroid reception at the endometrial tissue level. The detection of proteins P27 and cyclin E in the cytoplasm of glandular and stromal cells reflects the deficient block of a cell cycle essential for an adequate implantation window. The detected features of the superficial endometrial ultrastructure may be an additional indicator of the adequacy of endometrial secretory maturation. The essential histological, immunohistochemical, and ultrastructural features of the endometrium in infertility give valuable information that complements the traditional clinical classifications. Evaluation of the endometrial morphofunctional state opens up fresh opportunities to ensure an individual approach when using the regimens of assisted reproductive technologies.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Immunohistochemical examination of PNAd, α4β1 integrin and MUC-2 expressions in the secretary phase endometrium of women diagnosed with recurrent implantation failure.
J Reprod Immunol
December 2024
Department of Histology and Embryology, Medical School, University of Cukurova, Adana, Turkiye.
Objective: Successful embryo implantation is contingent upon the intricate interaction between the endometrium and the blastocyst. Recurrent implantation failure (RIF) signifies the clinical challenge of failing pregnancy post-transfer of high-quality embryos, fresh or frozen, in at least three in vitro fertilization (IVF) cycles, often in women under 40 years. Recent studies identify impaired blastocyst maternal tissue communication among recurrent implantation failure causes.
View Article and Find Full Text PDFEvaluating round window niche visibility in cochlear implantation: anatomical insights and electrode insertion strategies.
Eur Arch Otorhinolaryngol
January 2025
Department of Radiology, Istanbul Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
Purpose: Cochlear implantation (CI) surgery is essential for restoring hearing in individuals with severe sensorineural hearing loss. Accurate placement of the electrode within the cochlea is essential for successful auditory outcomes and minimizing complications. This study aims to analyze the relationship between the round window niche (RWN) alignment, its visibility during surgery, and the impact on surgical techniques and outcomes.
View Article and Find Full Text PDFTime-series single-cell transcriptomic profiling of luteal-phase endometrium uncovers dynamic characteristics and its dysregulation in recurrent implantation failures.
Nat Commun
January 2025
Shenzhen Key Laboratory of Fertility Regulation, Reproductive Medicine Center, the University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Understanding human endometrial dynamics in the establishment of endometrial receptivity remains a challenge, which limits early diagnosis and treatment of endometrial-factor infertility. Here, we decode the endometrial dynamics of fertile women across the window of implantation and characterize the endometrial deficiency in women with recurrent implantation failure. A computational model capable of both temporal prediction and pattern discovery is used to analyze single-cell transcriptomic data from over 220,000 endometrial cells.
View Article and Find Full Text PDFComparison of CT-like MRI sequences for preoperative planning of cochlear implantation using super-high-resolution CT as a reference.
Eur Radiol Exp
January 2025
Guilloz Imaging Department, Central Hospital, University Hospital Center of Nancy, 29 Avenue du Marechal de Lattre de Tassigny, 54000, Nancy, France.
Background: We evaluated the accuracy of magnetic resonance imaging (MRI) computed tomography (CT)-like sequences compared to normal-resolution CT (NR-CT) and super-high-resolution CT (SHR-CT) for planning of cochlear implantation.
Methods: Six cadaveric temporal bone specimens were used. 3-T MRI scans were performed using radial volumetric interpolated breath-hold (STARVIBE), pointwise-encoding time reduction with radial acquisition (PETRA), and ultrashort time of echo (UTE) sequences.
Women with breast implants have higher adjusted abnormal cardiac testing and coronary angiography but lower coronary intervention.
Am J Med
December 2024
University of Arizona, College of Medicine, Phoenix.
Background: Breast implants interfere with myocardial perfusion imaging (SPECT) and echocardiographic windows leading to increased false positive results. To validate this concept, we hypothesized that patients with breast implants should have higher positive cardiac testing and coronary angiogram with lower percutaneous coronary intervention (PCI) rates compared to women without a breast implant.
Methods: Using ICD 10 codes for breast implants, abnormal results of cardiac functional study, coronary angiogram, and percutaneous coronary interventions, we evaluated any association between these parameters in adult women with breast implants utilizing the National Inpatient Sample (NIS) database.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!