An electronic survey was used to assess perceptions of the disruption caused by the August transition and explore support for possible solutions. In total, 763 responses from members and fellows of the Royal College of Physicians of Edinburgh and the Society of Acute Medicine were received. The majority perceived the August transition to have a negative impact on patient care (93.1%), patient safety (90.4%) and training (57.8%) for a period of up to one month. In total 680/737 respondents wished to shift away from a single changeover day, with strong support for a staggered changeover by grade. Changes to consultant working practices were felt to be beneficial, especially the cancellation of outpatient clinics (75%) and the restriction of leave (69.9%). Further use of shadowing (74.1%) and online induction (37%) was supported. This paper concludes that there is a high degree of support for structured change to the current provisions for junior doctor changeover.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873737 | PMC |
http://dx.doi.org/10.7861/clinmedicine.11-4-322 | DOI Listing |
Explor Res Clin Soc Pharm
March 2025
University of Houston College of Pharmacy, Health 2, 4349 Martin Luther King Blvd, Houston, TX 77204, United States.
Background: The hospital at home (HaH) model has become more prevalent in the American healthcare system due to its ability to decrease acute care costs and readmission risk. Recent publications have provided guidance on optimizing medication management and patient safety by leveraging clinical pharmacy services. There is limited data on pharmacoeconomic impact of HaH implementation, specifically in underinsured patients.
View Article and Find Full Text PDFCurr Med Res Opin
January 2025
Otsuka Pharmaceutical Development & Commercialization Inc., Princeton, NJ, USA.
Aripiprazole 2-month ready-to-use (Ari 2MRTU) is a long-acting injectable antipsychotic that was approved for use in Europe in March 2024, for the maintenance treatment of schizophrenia in adult patients stabilized with aripiprazole; it is administered via gluteal intramuscular injection once every two months. This review examines population pharmacokinetic model-based simulations relevant to the use of Ari 2MRTU in Europe, accompanied by expert commentary that contextualizes the simulations and highlights the potential implications of the availability of Ari 2MRTU for patients, caregivers, and clinicians. Various simulations conducted across 8 weeks (representing the first dosing interval), or 32 weeks (representing maintenance dosing) demonstrated an aripiprazole exposure profile for Ari 2MRTU that was similar to aripiprazole once-monthly (AOM), but with an extended dosing interval.
View Article and Find Full Text PDFJ Antimicrob Chemother
January 2025
Department of Pharmacy, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Objectives: Candida glabrata is the second most common species responsible for invasive candidiasis, including candidaemia. Echinocandins are typically the first-line therapy for C. glabrata candidaemia, with the option to transition to oral fluconazole.
View Article and Find Full Text PDFInt J Behav Nutr Phys Act
January 2025
MRC Epidemiology Unit, University of Cambridge Level 3 Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0SL, UK.
Background: The workplace is an important determinant of health that people are exposed to for the first-time during adolescence or early adulthood. This study investigates how diet, physical activity, and sleep change as people aged 16-30 years transition into work and whether this varies for different individuals and job types.
Methods: Multilevel linear regression models assessed changes in fruit and vegetable intake, sleep duration, and physical activity among 3,302 UK Household Longitudinal Study (UKHLS) participants aged 16-30 years, who started work for the first time between 2015 and 2023.
On August 24, 2023, Japan controversially decided to discharge nuclear wastewater from the Fukushima Daiichi Nuclear Power Plant into the ocean, initiating intense domestic and global debates. This study employs a mixed-method approach, integrating quantitative evolutionary game theory and qualitative data analysis to explore the strategic dynamics among Japan, other nations, and the Japan Fisheries Association regarding this decision. The data includes international environmental reports and economic statistics, served as the basis for simulating decision-making processes under various legal, economic, and environmental pressures.
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