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Typical endocrine disrupting chemicals in newborns with congenital hypothyroidism: Concentrations, exposure assessment, and potential risks.
J Hazard Mater
December 2024
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; School of Environment, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, School of Environment and Health, Jianghan University, Wuhan 430056, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:
Congenital hypothyroidism (CH) has been reported as a prevalent endocrine disorder in newborns. Endocrine disrupting chemicals (EDCs) have been widely detected in humans and can influence endocrine function, especially thyroid function, and neonates as a susceptible population may be more prone to suffer from CH through exposure to various EDCs. In this study, the concentrations and composition profiles of several typical EDCs were determined in 266 serum samples collected from newborns with (n = 136) and without CH (n = 130) in Beijing, China from 2018 to 2020.
View Article and Find Full Text PDFInvestigating the mechanisms of action of thyroid disruptors: A multimodal approach that integrates in vitro and metabolomic analysis.
Toxicol In Vitro
October 2024
Bayer Crop Science, Sophia Antipolis, France. Electronic address:
The thyroid gland, a vital component of the endocrine system, plays a pivotal role in regulating metabolic processes, growth, and development. To better characterize thyroid system disrupting chemicals (TSDC), we followed the next-generation risk assessment approach, which further considers the mechanistic profile of xenobiotics. We combined targeted in vitro testing with untargeted metabolomics.
View Article and Find Full Text PDFPrenatal Phenol and Paraben Exposures and Adverse Birth Outcomes: A Prospective Analysis of U.S. Births.
Environ Int
January 2024
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Article Synopsis
- Synthetic chemicals like bisphenols, parabens, and triclosan may contribute to preterm birth (PTB) and low birth weight (LBW) due to their ability to disrupt hormones and cause oxidative stress.
- A study with 3,619 mother-infant pairs found that higher concentrations of benzophenone-3 and methylparaben during pregnancy were linked to lower birth weight and increased odds of being small for gestational age (SGA).
- The findings suggest that while the effects are concerning, certain compounds like 2,4-dichlorophenol showed an unexpected association with lower odds of low birth weight, indicating complex interactions that need further investigation.
The Hidden Threat: Endocrine Disruptors and Their Impact on Insulin Resistance.
Cureus
October 2023
Pathology and Laboratory Medicine, American University of Antigua, Coolidge, ATG.
The association between Insulin resistance, a global health issue, and endocrine disruptors (EDCs), chemicals interfering with the endocrine system, has sparked concern in the scientific community. This article provides a comprehensive review of the existing literature regarding the intricate relationship between EDCs and insulin resistance. Phthalates, commonly found in consumer products, are well-established EDCs with documented effects on insulin-signaling pathways and metabolic processes.
View Article and Find Full Text PDFCetaceans as bio-indicators revealed the increased risks of triclosan exposure and associated thyroid hormone disruption during the COVID-19 pandemic.
J Hazard Mater
October 2023
School of Marine Sciences, Zhuhai Key Laboratory of Marine Bioresources and Environment, Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering, Pearl River Estuary Marine Ecosystem Research Station, Ministry of Education, Sun Yat-Sen University, Southern Marine Science and Engineering Guangdong Laboratory, Zhuhai 519082, China. Electronic address:
The global surge in disinfection practices from the COVID-19 response has raised concerns about the marine exposure to the hazardous ingredients in disinfectant products, including triclosan (TCS) and triclocarban (TCC). However, there are very limited studies on the response of marine TCS and TCC (TCs) loading to the COVID-19 pandemic. Here we used cetaceans as bio-indicators for a long-term retrospective analysis of TCs loading to the South China Sea (SCS) between 2004 and 2022.
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