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How I do it: Modified operation technique for MR Conditional OSIA 3: anterior based flap for covering the implant.
Eur Arch Otorhinolaryngol
January 2025
Department of Otorhinolaryngology, Head and Neck Surgery, Ruhr Universitiy Bochum, St. Elisabeth-Hospital, Bochum, Germany.
Background: The new OSIA3 is 1.5 T and 3 T MR-Conditional. Skin related issues are the most common complications.
View Article and Find Full Text PDFStroke Prevention in Hispanic Children with Sickle Cell Anemia: the SACRED trial.
Blood Adv
January 2025
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States.
Sickle cell anemia (SCA) is recognized globally, but little is known about affected Hispanic populations. In partnership with Dominican Republic, a Hispanic Caribbean Island with a large SCA population, a TCD screening program provided hydroxyurea to children with conditional velocities. Building local capacity, ten Dominican medical graduates were certified in TCD examinations and trained in hydroxyurea management.
View Article and Find Full Text PDFEnergy of Functional Brain States Correlates With Cognition in Adolescent-Onset Schizophrenia and Healthy Persons.
Hum Brain Mapp
January 2025
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Adolescent-onset schizophrenia (AOS) is relatively rare, under-studied, and associated with more severe cognitive impairments and poorer outcomes than adult-onset schizophrenia. Neuroimaging has shown altered regional activations (first-order effects) and functional connectivity (second-order effects) in AOS compared to controls. The pairwise maximum entropy model (MEM) integrates first- and second-order factors into a single quantity called energy, which is inversely related to probability of occurrence of brain activity patterns.
View Article and Find Full Text PDFDetection of aberrant locomotor activity in a mouse model of lung cancer via home cage monitoring.
Front Oncol
December 2024
Department of Experimental Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Introduction: Lung cancer is the first cause of cancer death in the world, due to a delayed diagnosis and the absence of efficacy therapies. KRAS mutation occurs in 25% of all lung cancers and the concomitant mutations in LKB1 determine aggressive subtypes of these tumors. The improvement of therapeutical options for KRASG12C mutations has increased the possibility of treating these tumors, but resistance to these therapies has emerged.
View Article and Find Full Text PDFGliomagenesis mimics an injury response orchestrated by neural crest-like cells.
Nature
January 2025
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Glioblastoma is an incurable brain malignancy. By the time of clinical diagnosis, these tumours exhibit a degree of genetic and cellular heterogeneity that provides few clues to the mechanisms that initiate and drive gliomagenesis. Here, to explore the early steps in gliomagenesis, we utilized conditional gene deletion and lineage tracing in tumour mouse models, coupled with serial magnetic resonance imaging, to initiate and then closely track tumour formation.
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