AI Article Synopsis
- CA-MRSA infections are often linked to strains containing the Panton-Valentine leukocidin (PVL) gene, but its impact on the USA300 strain is unclear.
- Researchers created a skin and soft tissue infection model in rabbits to explore whether PVL contributes to USA300's ability to cause infections compared to other virulence factors.
- The study found that while Hla, PSMα, and Agr are important for USA300's infection process, there was no evidence that PVL plays a significant role.
Article Abstract
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are frequently associated with strains harboring genes encoding Panton-Valentine leukocidin (PVL). The role of PVL in the success of the epidemic CA-MRSA strain USA300 remains unknown. Here we developed a skin and soft tissue infection model in rabbits to test the hypothesis that PVL contributes to USA300 pathogenesis and compare it with well-established virulence determinants: alpha-hemolysin (Hla), phenol-soluble modulin-alpha peptides (PSMα), and accessory gene regulator (Agr). The data indicate that Hla, PSMα, and Agr contribute to the pathogenesis of USA300 skin infections in rabbits, whereas a role for PVL could not be detected.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156927 | PMC |
| http://dx.doi.org/10.1093/infdis/jir441 | DOI Listing |
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