Objective: To explore the chromosome karyotypes in children with mental retardation.
Methods: The peripheral blood lymphocytes from 92 children with congenital mental retardation were cultured and analysed by the G-band technique.
Results: Of the 92 cases, 43 cases (47%) showed chromosome abnormalities. Autosomal abnormalities were found in 35 cases (38%) and sex chromosome abnormalities were found in 8 cases (9%). A novel abnormal karyotype 45, XX, psu dic (11;9) (p15;p24) was found in a child.
Conclusions: Chromosome abnormalities may be important cytogenetic factors for congenital mental retardation. Cytogenetic chromosome karyotypic analysis appears to be an important method for genetic screening of congenital mental retardation.
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