AI Article Synopsis
- Argonaute proteins play a crucial role in the microRNA pathway, with a specific focus on the distinct functions of Ago1 and Ago2.
- Overexpression of Ago1 in neuroblastoma cells slows down their cell cycle, reduces movement, and increases cell death when exposed to UV light.
- Increased levels of p53 and evidence from GEO Profiles suggest that Ago1 could act as a tumor-suppressor, opposing cell proliferation rates.
Article Abstract
Argonaute are a conserved class of proteins central to the microRNA pathway. We have highlighted a novel and non-redundant function of Ago1 versus Ago2; the two core factors of the miRNA-associated RISC complex. Stable overexpression of Ago1 in neuroblastoma cells causes the cell cycle to slow down, a decrease in cellular motility and a stronger apoptotic response upon UV irradiation. These effects, together with a significant increase in p53 levels, suggest that Ago1 may act as a tumor-suppressor factor, a function also supported by GEO Profiles microarrays that inversely correlate Ago1 expression levels with cell proliferation rates.
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| http://dx.doi.org/10.1016/j.febslet.2011.08.003 | DOI Listing |
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