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http://dx.doi.org/10.1128/MCB.05974-11 | DOI Listing |
RSC Adv
January 2025
Gansu Zhongshang Food Quality Test and Detection Co., Ltd Lanzhou 730010 China.
Ferrihydrite (Fh), a widely distributed mineral in the environment, plays a crucial role in the geochemical cycling of elements. This study used experimental and computational approaches to investigate the adsorption behavior of seven heavy metal ions on Fh. The pH edge analysis revealed that the adsorption capacity followed the order: Pb > Cu > Zn > Cd > Ni > Co > Mn, with Pb showed the highest adsorption.
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January 2025
Key Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area (Ningxia Medical University), Ministry of Education, School of Pharmacy, Ningxia Medical University 1160 Shengli Street Yinchuan 750004 China
The Keap1 (Kelch-like ECH-Associating Protein 1)-Nrf2 (Nuclear Factor Erythroid 2-Related Factor 2)-ARE (Antioxidant Response Element) signaling pathway plays a crucial role in the oxidative stress response and has been linked to the development and progression of various diseases. Its influence on cerebral ischemia/reperfusion (I/R) injury has garnered significant attention. In our study, we investigated the effect of compound 2, a non-covalent inhibitor of the Keap1-Nrf2 interaction, which was previously discovered by our research group.
View Article and Find Full Text PDFNoncovalent carbon bonding (C-bonding), a recently explored σ-hole interaction, has primarily been characterized through X-ray structural and computational studies. Evidence of C-bonds in solution is scarce, especially in highly polar solvents like DMSO where solvation effects typically overshadow weak non-covalent interactions. In this work, we present three novel spiroisatin-based -acyl hydrazones (1-3) in which C-bonds play a critical role in stabilizing the conformation in solution.
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January 2025
Research Institute for Convergence of Basic Science, Hanyang University Seoul 04763 Republic of Korea
Given that stomach cancer is the fourth leading cause of cancer-related death, there is a need to develop new drugs. Among various methods, metal-based coordination compounds are considered as an efficient strategy against this type of cancer. Similarly, the benzimidazole moiety plays a crucial role in biology; thus, various benzimidazole-based compounds have been found to be active as potential anticancer drugs and are currently used in clinical trials.
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January 2025
Graduate School of Environmental Symbiotic System Major, Nippon Institute of Technology 4-1 Gakuendai, Miyashiro Saitama 345-8501 Japan.
Coiled-coil protein carrier (CCPC) 140 is a rigid and anisotropically structured cationic coiled-coil artificial protein that has displayed up to a 1000 times higher level of cellular internalization activity than that of unstructured cell-penetrating peptides. Previous studies have demonstrated that CCPC 140's rigid and anisotropic structural properties and cationic surface properties are important for its superior cellular internalization activity. In this study, we investigated whether each physicochemical characteristic of CCPC 140 effectively contributed to activating the cellular internalization pathway.
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