Background: The study was conducted to confirm the mechanism of action of the Adiana permanent contraception device by means of histologic analysis of long-term specimens.
Study Design: Fifteen specimens were obtained from eight subjects undergoing hysterectomy 2 to 4 years after the Adiana procedure. Serial sections were stained with hematoxylin and eosin, as well as epithelial membrane antigen immunostain.
Results: A normal foreign body reaction with minimal chronic inflammatory changes was observed in all specimens. Immunostaining for epithelial membrane antigen was absent in the interstitial tissue surrounding the matrix.
Conclusion: Histologic analysis of long-term specimens supports the mechanism of action of the Adiana permanent contraception device.
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| http://dx.doi.org/10.1016/j.contraception.2011.01.008 | DOI Listing |
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