The paper reviews the literature on oral modifications presented by subjects affected by beta-thalassemia, an hereditary hemopathy present in significant numbers in some areas of Italy. Following a description of the clinical characteristics of the disease, the paper focuses on the genetic alterations leading to the hemopathy and their implication in the onset of the thalassemic state.
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Quality of Life Outcomes in a Pediatric Thalassemia Population in Egypt.
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c Department of Clinical Genetics , National Research Centre, Cairo , Egypt.
Thalassemia is a disorder of hemoglobin (Hb) synthesis characterized by chronic hemolysis. In β-thalassemias major (β-TM), patients require regular transfusion at an early age due to severe anemia. Subsequently, intensive chelation therapy is initiated to mitigate the effects of the resultant iron overload.
View Article and Find Full Text PDF[Beta-thalassemia and its orodental implications. II. A clinical study].
Minerva Stomatol
January 1990
Università degli Studi di Napoli II, Facoltà di Medicina e Chirurgia, Istituto di Discipline Odontostomatologiche.
The paper reports the findings of a study of 46 subjects affected by beta-thalassemia major who underwent periodic transfusion therapy. A reduced incidence of the caries process was observed, above all in subjects treated from the first months of life. After a short review of the main problems posed by these patients during dental treatment, the Authors propose a course of preventive antibiotic treatment to be carried out before the start of dental work.
View Article and Find Full Text PDF[Beta-thalassemia and its orodental implications. I. The clinical considerations].
Minerva Stomatol
January 1990
Università degli Studi di Napoli II, Facoltà di Medicina e Chirurgia, Istituto di Discipline Odontostomatologiche.
The paper reviews the literature on oral modifications presented by subjects affected by beta-thalassemia, an hereditary hemopathy present in significant numbers in some areas of Italy. Following a description of the clinical characteristics of the disease, the paper focuses on the genetic alterations leading to the hemopathy and their implication in the onset of the thalassemic state.
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