The present study was carried out to investigate the anti-inflammatory effect of the hexane extract of the leaves from Clusia nemorosa G. Mey, called HECn, using carrageenan-induced mice pleurisy and cotton pellet-induced mice granuloma. Additionally, the ability of HECn to affect both neutrophil migration as viability was investigated by use of the Boyden chamber assay and flow cytometry, respectively. The HECn significantly inhibited exudation, total leukocytes and neutrophils influx, as well as TNFα levels in carrageenan-induced pleurisy. However, the extract not suppressed the granulomatous tissue formation in the cotton pellet-induced granuloma test. Experiments performed in vitro revealed that HECn on human neutrophils inhibited a dose-dependent manner the CXCL1-induced neutrophil chemotaxis. Furthermore, HECn also inhibited the chemoattraction of human neutrophils induced by formyl-methionyl-leucyl-phenylalanine (fMLP), leukotriene B4 (LTB4) and platelet activating factor (PAF) in a Boyden chamber. However, this same treatment not was able to induce apoptosis. The results obtained in this study showed that the extract from leaves of C. nemorosa possess a potent inhibitory activity in acute model of inflammation, being the effects mediated, in part, by inhibition of neutrophil responsiveness. These results indicate that C. nemorosa could be a good source for anti-inflammatory compounds.
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http://dx.doi.org/10.1007/s10753-011-9372-y | DOI Listing |
Plants (Basel)
July 2024
Departamento de Biologia Vegetal, Universidade Federal de Viçosa, Viçosa 36570-000, MG, Brazil.
The Brazilian Atlantic Forest, renowned for its exceptional species richness and high endemism, acts as a vital reservoir of terrestrial biodiversity, often referred to as a biodiversity hotspot. Consequently, there is an urgent need to restore this forest to safeguard certain species and to unravel the ecophysiological adaptations of others. This study aims to integrate some physiological parameters, including gas exchange and chlorophyll a fluorescence, with anatomical and metabolic techniques to elucidate how five different native species (, , , , and ), each occupying distinct ecological niches, respond to seasonal variations in rainfall and their consequences.
View Article and Find Full Text PDFAn Acad Bras Cienc
August 2018
Instituto de Biologia, Universidade Estadual de Campinas, Cidade Universitária Zeferino Vaz, 13083-862 Campinas, SP, Brazil.
The apolar fractions components of fruit latex of twelve species of Clusia belonging to four different taxonomic sections were examined by GC-MS. The latex of Clusia is characterised by large amounts of sesquiterpene hydrocarbons as major constituents like germacrene D: C. paralicola (44.
View Article and Find Full Text PDFIntegr Comp Biol
July 2016
*Institut de Recherche sur la Biologie de l'Insecte (IRBI, CNRS UMR 7261), Université François Rabelais, Faculté des Sciences et Techniques, Tours 37200, France.
Most tropical ectotherms live near their physiological limits for temperature. Substantial ecological effects of global change are predicted in the tropics despite the low amplitude of temperature change. These predictions assume that tropical ectotherms experience air temperature as measured by weather stations or predicted by global circulation models.
View Article and Find Full Text PDFBraz J Microbiol
October 2016
Departamento de Ciências Biológicas, Universidade Estadual de Feira de Santana, Feira de Santana, BA, Brazil.
We investigated the composition and structure of fungal communities associated with leaf litter generated by Clusia nemorosa and Vismia guianensis that belong to phylogenetically-related botanical families and exist together in a remnant of the Atlantic Forest in Bahia, Brazil. Samplings were conducted during wet (June 2011) and dry (January 2013) seasons in Serra da Jibóia. The fungi were isolated using particle filtration and the 1,832 isolates represented 92 taxa.
View Article and Find Full Text PDFMolecules
August 2015
Departamento de Química, Universidade Federal Rural do Rio de Janeiro, 23890-000 Seropédica, Brazil.
Clusia nemorosa has been widely used in folk medicine to treat various ailments, including headaches and inflammation. Investigation of the fruits of Clusia nemorosa (Clusiaceae) led to the isolation and characterization of a new phloroglucinol derivative, named 6S,8S,28S-nemorosic acid (1), together with seven known compounds: friedelin (2), β-sitosterol (3), stigmasterol (4), β-sitosterol glycoside (5), kaempferol (6), quercetin (7) and dimethyl citrate (8). The structures were determined by extensive 1D- and 2D-NMR, CD and MS spectroscopic analyses.
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