AI Article Synopsis
- Diabetes mellitus and metabolic syndrome are linked to diastolic dysfunction and lower stress tolerance, which can worsen heart failure after a heart attack.
- Factors such as insulin resistance and high blood sugar levels impact heart cell function and blood flow regulation.
- The review covers epidemiology, causes, diagnosis, and treatment of heart failure in diabetic patients post-myocardial infarction, highlighting new strategies for future research.
Article Abstract
Diabetes mellitus, the metabolic syndrome, and the underlying insulin resistance are increasingly associated with diastolic dysfunction and reduced stress tolerance. The poor prognosis associated with heart failure in patients with diabetes after myocardial infarction is likely attributable to many factors, important among which is the metabolic impact from insulin resistance and hyperglycemia on the regulation of microvascular perfusion and energy generation in the cardiac myocyte. This review summarizes epidemiologic, pathophysiologic, diagnostic, and therapeutic data related to diabetes and heart failure in acute myocardial infarction and discusses novel perceptions and strategies that hold promise for the future and deserve further investigation.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208100 | PMC |
| http://dx.doi.org/10.1007/s11897-011-0070-8 | DOI Listing |
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