When a transcription factor is modified by small ubiquitin-like modifier (SUMO), this usually represses its transcriptional activity. In this issue of Developmental Cell, Lee et al. (2011) use a knockin mouse model to show that SUMO-less SF-1 binds and activates inappropriate targets, causing changes in cell fates and endocrine abnormalities.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162251 | PMC |
| http://dx.doi.org/10.1016/j.devcel.2011.07.015 | DOI Listing |
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