AI Article Synopsis
- A 19-year-old female kidney transplant recipient with cystinosis developed lupus nephritis, raising concerns about a possible link to her cysteamine therapy.
- The patient's clinical and immunologic symptoms did not improve after stopping cysteamine, suggesting the lupus was not drug-induced.
- This case highlights the need for clinicians to recognize autoimmune issues in cystinosis patients, as it may be the first report of such lupus occurrence in this context.
Article Abstract
A case of lupus nephritis in an adult female kidney transplant recipient with cystinosis under cysteamine therapy is reported. Previous reports of new-onset lupus in cystinotic patients have focused in a possible relationship of lupus with cysteamine therapy, but no obvious pathophysiological association has been disclosed. The authors present a case of a 19-year-old female kidney transplant recipient with cystinosis admitted for acute allograft dysfunction, with clinical and immunologic manifestations of lupus nephritis. Cysteamine was considered as a potential cause of drug-induced lupus, and we temporarily interrupted this drug. The clinical picture, the negativity of antihistone antibodies, the nondisappearance of antinuclear antibodies after discontinuation of the drug, and the clinical stability after resuming cysteamine therapy suggested that the underlying mechanism of lupus was unrelated to the drug. This may be the first report of new-onset lupus in a kidney transplant recipient with cystinosis. Clinicians should be aware of the association of autoimmune abnormalities in patients with cystinosis.
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| http://dx.doi.org/10.1016/j.transproceed.2011.05.009 | DOI Listing |
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