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Investigating the relationship between the immune response and the severity of COVID-19: a large-cohort retrospective study.
Front Immunol
January 2025
Physics Department, International School for Advanced Studies (SISSA), Trieste, Italy.
The COVID-19 pandemic has left an indelible mark globally, presenting numerous challenges to public health. This crisis, while disruptive and impactful, has provided a unique opportunity to gather precious clinical data extensively. In this observational, case-control study, we utilized data collected at the Azienda Sanitaria Universitaria Friuli Centrale, Italy, to comprehensively characterize the immuno-inflammatory features in COVID-19 patients.
View Article and Find Full Text PDFAnalytical sensitivity factors from distributions of time of flight of photons for near-infrared spectroscopy studies in multilayered turbid media.
J Biomed Opt
January 2025
CIFICEN (UNCPBA - CICPBA - CONICET), Tandil, Argentina.
Significance: In the last years, time-resolved near-infrared spectroscopy (TD-NIRS) has gained increasing interest as a tool for studying tissue spectroscopy with commercial devices. Although it provides much more information than its continuous wave counterpart, accurate models interpreting the measured raw data in real time are still lacking.
Aim: We introduce an analytical model that can be integrated and used in TD-NIRS data processing software and toolkits in real time.
Management of Traumatically Intruded Permanent Incisors during an Ongoing Orthodontic Treatment.
Contemp Clin Dent
December 2024
Department of Orthodontics and Dentofacial Orthopedics, SDM College of Dental Sciences, A Constituent Unit of Shri Dharmasthala Manjunatheshwara University, Dharwad, Karnataka, India.
Intrusive luxation is one of the most severe types of dental trauma that needs immediate intervention. Various treatment modalities are passive, active, and surgical repositioning performed to prevent healing complications such as root resorption, pulp necrosis, ankylosis, and infraocclusion of the traumatized teeth. This case report discusses a patient with traumatically intruded incisors while undergoing orthodontic treatment.
View Article and Find Full Text PDFA Rare Case of Linear Phlebolith: Foreign Body Discovered in the Femoral Vein.
Case Rep Surg
January 2025
Division of Vascular Surgery, Department of Surgery, College of Medicine, King Saud University, Riyadh 11322, Saudi Arabia.
Phlebolith is a term that refers to round-shaped calcified thrombi commonly located in the pelvic region. The occurrence of dense, linear calcifications or phlebolith-like formations within the soft tissues of the lower extremities, particularly in the superficial femoral, greater saphenous, or popliteal veins, is rare. This study presents the case of a 73-year-old woman who was being evaluated for postmenopausal bleeding.
View Article and Find Full Text PDFAPOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology.
Mol Neurodegener
January 2025
Department of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, 92697-4545, USA.
Background: Apolipoprotein E ε4 (APOE4) is the strongest genetic risk factor for late-onset Alzheimer's disease (LOAD). A recent case report identified a rare variant in APOE, APOE3-R136S (Christchurch), proposed to confer resistance to autosomal dominant Alzheimer's Disease (AD). However, it remains unclear whether and how this variant exerts its protective effects.
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