Background: Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a death ligand currently under clinical trials for cancer. The molecular profile of TRAIL and TRAIL receptors has not yet been mapped for patients with laryngeal squamous cell carcinoma (SCC) or patients with oral cavity squamous cell carcinoma (OCSCC).
Methods: Paraffin-embedded tissues from 60 patients with laryngeal SCC and 14 patients with OCSCC were retrospectively analyzed using immunohistochemistry.
Results: An increase in decoy-R1 (DcR1) but a decrease in decoy-R2 (DcR2) expression were observed in patients with laryngeal SCC and in patients with OCSCC compared with control individuals with benign lesions. Clinical and pathologic grading revealed distinctive TRAIL and TRAIL receptor profiles in patients with squamous cell carcinoma of the head and neck (SCCHN).
Conclusions: TRAIL and a TRAIL receptor expression profile might be useful to follow-up disease progression by virtue of its connection with clinical staging and pathologic grading in patients with laryngeal SCC.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/hed.21598 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Scant Evidence for Long-Range Atmospheric Transport of Particle-Bound Benzotriazole Ultraviolet Stabilizers.
Environ Sci Technol
January 2025
Department of Physical and Environmental Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, Ontario, Canada M1C 1A4.
Despite benzotriazole UV stabilizers (BT-UVs) being widely used since the 1960s, few empirical data on their atmospheric presence exist. UV-328 was added to the Stockholm Convention on Persistent Organic Pollutants, based in part on model calculations indicating atmospheric long-range transport potential. We investigated the atmospheric occurrence of BT-UVs at multiple sites that differ greatly in their proximity to potential sources.
View Article and Find Full Text PDF"Minimal-Advice" on Salt Intake: Results of a Multicentre Pilot Randomised Controlled Trial on Hypertensive Patients.
High Blood Press Cardiovasc Prev
January 2025
Department of Clinical Medicine and Surgery, ESH Excellence Center of Hypertension, "Federico II" University of Naples Medical School, Via S. Pansini, 5, 80131, Naples, Italy.
Introduction: A strong and well-known association exists between salt consumption, potassium intake, and cardiovascular diseases. MINISAL-SIIA results showed high salt and low potassium consumption in Italian hypertensive patients. In addition, a recent Italian survey showed that the degree of knowledge and behaviour about salt was directly interrelated, suggesting a key role of the educational approach.
View Article and Find Full Text PDFMultidimensional Classification and Prediction of Outcome Following Traumatic Brain Injury.
J Head Trauma Rehabil
January 2025
Author Affiliations: Monash-Epworth Rehabilitation Research Centre, School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia (Prof Ponsford and Drs Spitz, Pyman, Carrier, Hicks, and Nguyen); Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia (Dr Spitz); TIRR Memorial Hermann Research Center Houston, Texas (Drs Sander and Sherer); and H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine & Harris Health System, Houston, Texas (Drs Sander and Sherer).
Objectives: This study aimed to identify outcome clusters among individuals with traumatic brain injury (TBI), 6 months to 10 years post-injury, in an Australian rehabilitation sample, and determine whether scores on 12 dimensions, combined with demographic and injury severity variables, could predict outcome cluster membership 1 to 3 years post-injury.
Setting: Rehabilitation hospital.
Participants: A total of 467 individuals with TBI, aged 17 to 87 (M = 44.
Simulation-based training program effect on pediatric nurses' knowledge and performance regarding heel-prick during newborn blood screening test.
BMC Nurs
January 2025
Faculty of Applied Medical Sciences in Alnamas, University of Bisha, 255, Al Nakhil, Al-Namas, 67714, Saudi Arabia.
Background: One of the best ways to impart important skills to trainees is through simulation-based training, which is more reliable than the conventional clinical examination method. It is used in pediatric nursing training to allow nurses to practice and improve their clinical and conversational skills during an actual child encounter. A heel-prick is a complex psychomotor task that requires skill and knowledge from the pediatric nurse performing the procedure while applying for the National Newborn Screening Program.
View Article and Find Full Text PDFExecutive functions in adults born small for gestational age at term: a prospective cohort study.
Sci Rep
January 2025
Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
There are mixed findings regarding executive functioning in individuals born small for gestational age (SGA) at term and associations between performance-based and self-reported executive functions have yet to be examined in adults. In a prospective cohort study, 56 SGA and 68 non-SGA control participants were assessed at 32 years using the performance-based Trail Making Test (TMT) and the self-report questionnaire Behavior Rating Inventory of Executive Function - Adult Version (BRIEF-A). The SGA group used 1.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!