AI Article Synopsis
- The compound angustoline monohydrate, with the formula C(20)H(17)N(3)O(2)·H(2)O, has a complex structure featuring a fused system of five and six-membered rings.
- The benzimidazole and naphthyridin-1-one sections of the compound are almost planar but slightly twisted due to the tetrahedral connections within the rings.
- In the crystal structure, various functional groups, including amino and hydroxyl groups as well as a water molecule, engage in hydrogen bonding, creating a three-dimensional network that stabilizes the compound.
Article Abstract
THE TITLE COMPOUND (TRIVIAL NAME: angustoline monohydrate), C(20)H(17)N(3)O(2)·H(2)O, features a fused-ring system formed by one five- and four six-membered rings. The nearly planar benzimidazole portion (r.m.s. deviation = 0.008 Å) and the nearly planar 2,7-naphthyridin-1-one portion (r.m.s. deviation = 0.022 Å) of the fused-ring system are slightly twisted, with a dihedral angle of 9.47 (8)°, owing to the tetra-hedral nature of the two methyl-ene linkages in the central six-membered ring. The secondary N atom acts as a hydrogen-bond donor to the water molecule of crystallization. In the crystal, the amino and hy-droxy groups, and the water mol-ecule are engaged in hydrogen bonding, generating a three-dimensional network.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151776 | PMC |
| http://dx.doi.org/10.1107/S1600536811022768 | DOI Listing |
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1-(1-Hy-droxy-eth-yl)-7,8-dihydro-indolo[2,3-a]pyridine-[3,4-g]quinolizin-5(13H)-one (angustoline) monohydrate from Nauclea subdita (Rubiaceae).
Acta Crystallogr Sect E Struct Rep Online
July 2011
Article Synopsis
- The compound angustoline monohydrate, with the formula C(20)H(17)N(3)O(2)·H(2)O, has a complex structure featuring a fused system of five and six-membered rings.
- The benzimidazole and naphthyridin-1-one sections of the compound are almost planar but slightly twisted due to the tetrahedral connections within the rings.
- In the crystal structure, various functional groups, including amino and hydroxyl groups as well as a water molecule, engage in hydrogen bonding, creating a three-dimensional network that stabilizes the compound.
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