AI Article Synopsis
- The compound discussed is a mefloquine-oxazolidine derivative with the molecular formula C(24)H(20)F(6)N(2)O(2).
- The molecular structure includes an oxazoline ring in an envelope conformation and a piperidine ring in a chair conformation, with certain residues oriented away from the quinoline group's C(6) ring.
- The crystal structure exhibits several types of interactions, including intramolecular hydrogen bonds and various intermolecular interactions such as C-H⋯O, C-H⋯F, and C-H⋯π bonds.
Article Abstract
In the title mefloquine-oxazolidine derivative, C(24)H(20)F(6)N(2)O(2), the oxazoline ring adopts an envelope conformation (the flap atom is N) and the piperidine ring has a chair conformation. The oxazoline and benzene residues lie away from the C(6) ring of the quinoline group and, to a first approximation, to one side of the plane through the ten atoms (r.m.s. deviation = 0.025 Å). An intra-molecular O-H⋯N(piperidine) hydrogen bond is present. The crystal packing features C-H⋯O, C-H⋯F and C-H⋯π(hy-droxy-benzene) inter-actions.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151884 | PMC |
| http://dx.doi.org/10.1107/S1600536811022379 | DOI Listing |
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