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Exploring the repository of de novo-designed bifunctional antimicrobial peptides through deep learning.
Elife
March 2025
Frontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Faculty of Medicine, Tianjin University, Tianjin, China.
Antimicrobial peptides (AMPs) are attractive candidates to combat antibiotic resistance for their capability to target biomembranes and restrict a wide range of pathogens. It is a daunting challenge to discover novel AMPs due to their sparse distributions in a vast peptide universe, especially for peptides that demonstrate potencies for both bacterial membranes and viral envelopes. Here, we establish a de novo AMP design framework by bridging a deep generative module and a graph-encoding activity regressor.
View Article and Find Full Text PDFRiverine antibiotic resistome along an anthropogenic gradient.
Front Microbiol
February 2025
Department of Technical Biogeochemistry, Helmholtz Centre for Environmental Research, Leipzig, Germany.
The introduction of antibiotic-resistant bacteria into riverine systems through the discharge of wastewater treatment plant (WWTP) effluent and agricultural waste poses significant health risks. Even when not pathogenic, these bacteria can act as reservoirs for antibiotic resistance genes (ARGs), transferring them to pathogens that infect humans and animals. In this study, we used fluorescence hybridization, qPCR, and metagenomics to investigate how anthropogenic activities affect microbial abundance and the resistome along the Holtemme River, a small river in Germany, from near-pristine to human-impacted sites.
View Article and Find Full Text PDFBio-electrosynthesis of polyhydroxybutyrate and surfactants in microbial fuel cells: a preliminary study.
Front Microbiol
February 2025
Laboratory of Systems Microbiology, Department of Microbial Sciences, University of Surrey, Guildford, United Kingdom.
Microbial Electrochemical Technology (MET) offers a promising avenue for CO utilization by leveraging the ability of chemolithotrophic microorganisms to use inorganic carbon in biosynthetic processes. By harnessing the power of electroactive bacteria, METs can facilitate the conversion of inorganic carbon into organic compounds. Therefore, this work combines biosurfactant production at the anode and PHB production at the cathode of Microbial Fuel Cells (MFCs), while testing the efficiency of Microbial Electrosynthesis Cells (MECs), and traditional culture in liquid media.
View Article and Find Full Text PDFAn integrated proteo-transcriptomics approach reveals novel drug targets against multidrug resistant .
Front Microbiol
February 2025
Department of Biophysics, University of Delhi South Campus, New Delhi, India.
Infections due to multidrug-resistant (MDR) are associated with severe morbidity and mortality, worldwide. Microbial drug resistance is a complex phenomenon which is conditioned by an interplay of several genomic, transcriptomic and proteomic factors. Here, we have conducted an integrated transcriptomics and proteomics analysis of MDR to identify genes which are differentially expressed at both mRNA and protein levels.
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