Chem Biol Interact
Institute of Biochemistry, College of Life Sciences, Zhejiang University, PR China.
Published: September 2011
FLZ is a synthetic novel squamosamide derivative and has previously been proved to be a potential drug for Parkinson's disease and Alzheimer's disease. FLZ has strong antioxidant activity, which implies that FLZ could eliminate excessive intracellular reactive oxygen species (ROS) in tumor cells and induce a pathway related to low cellular ROS levels, thereby inhibiting tumor cells proliferation. However, few reports have focused on the antitumor effects of FLZ. In this study, we investigated the antitumor efficacy of FLZ in HepG2 cells and the mechanism of cell growth inhibition. FLZ effectively inhibited HepG2 cell proliferation in a dose- and time-dependent manner; meanwhile, it was minimally toxic to normal cells. FLZ induced a significant decrease in oxidative stress through elimination of excessive intracellular ROS and strengthening of the glutathione antioxidant system. In addition, FLZ can effectively attenuate redundant [Ca(2+)](i), thereby avoiding uncontrolled amplification by Ca(2+)/ROS positive feedback. Furthermore, Western blot showed that FLZ inhibited phosphorylation of Akt and retinoblastoma protein (Rb), down-regulated the expressions of cyclin D1, cyclin E, cyclin-dependent kinase 2 (CDK2), and enhanced the expression of CDK inhibitor p27(kip1), while did not affect CDK4 expression. These results suggest that FLZ has potent anti-proliferative activity against malignant human hepatoma cells via modulation of the expression or activation of cell-cycle regulatory proteins, which are associated with decreased Ca(2+)/ROS levels, and indicate that FLZ is a potential liver cancer drug worthy of further research and development.
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http://dx.doi.org/10.1016/j.cbi.2011.07.004 | DOI Listing |
Plant Dis
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Guilin, Guangxi, China;
L. is a tropical fruit, cultivated in various provinces of China, such as Guangxi, Taiwan, and Yunnan. This fruit has good edible and medicinal value.
View Article and Find Full Text PDFBrain Res Bull
January 2025
State Key Laboratory of Bioactive Substance and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Xian Nong Tan Street, Beijing 100050, China; Department of Occupational and Environmental Health, School of Public Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian 116044, China. Electronic address:
Antibiotics (Basel)
December 2024
Centro de Ciências da Saúde, Universidade Federal do Maranhão, São Luís 65080-805, MA, Brazil.
: Antifungal resistance to azoles, coupled with the increasing prevalence of infections, represents a significant public health challenge and has driven the search for new natural compounds that can act as alternatives or adjuvants to the current antifungals. Ellagic acid (EA) has demonstrated antifungal activity; however, its effects are not fully understood. In this study, we investigated the in vitro anti- activity of EA and its ability to potentiate the effects of fluconazole (FLZ) on : The Minimum Inhibitory Concentration (MIC) of EA was determined by broth microdilution and its interaction with FLZ was assessed using a checkerboard assay.
View Article and Find Full Text PDFJ Asian Nat Prod Res
January 2025
State Key Laboratory of Bioactive Substance and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Compound FLZ has neuroprotective effects on Parkinson's disease (PD), while the precise mechanism remains unclear. In this study, we found that FLZ decreased PTEN/Akt activity in LPS-challenged BV2 cells. Neuroinflammatory responses suppressed by FLZ were abolished when PTEN or Src was inhibited.
View Article and Find Full Text PDFJ Plast Reconstr Aesthet Surg
January 2025
Department of Plastic Surgery and Hand Surgery, University Hospital Rechts der Isar, Munich Technical University, Ismanninger Str. 22, 81675 Munich, Germany; Department of Plastic Surgery and Burns, Alexandroupoli University Hospital, Democritus University of Thrace, Alexandroupoli, Greece; Department of Plastic Surgery, Eugenideio University Hospital, University of Athens, Athens, Greece. Electronic address:
Background: The authors' previous research suggested the hypothesis that aesthetic surgery in general has a positive impact on quality of life (QoL). This prospective study aimed to investigate the indication-specific effect on QoL in patients undergoing transaxillary endoscopic breast augmentation.
Methods: Seventy-seven patients underwent aesthetic breast augmentation.
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