The aim of this study was to determine the safety of imidocarb dipropionate in sheep. Imidocarb dipropionate (IMDP) was administered (2.4 mg/kg, intramuscular; i.m.) to 10 sheep, and blood samples were obtained 0, 1, 6, and 9 days after treatment. Hemacell counts, serum biochemical values, coagulation values, and serum oxidative status were measured. IMDP caused transient decreases in pH, actual bicarbonate, standard bicarbonate, total carbon dioxide, base excess in vivo, base excess in vitro, oxygen saturation, lactate dehydrogenase, and retinol levels and transient increases in serum creatine kinase-MB, blood urea nitrogen, and creatinine levels. IMDP decreased adenosine deaminase activity, antithrombin III, and superoxide dismutase activity and increased white blood cell counts. In conclusion, IMDP may change serum oxidative status and cause coagulation disorders during treatment in sheep.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3109/01480545.2011.589449 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Equine piroplasmosis: Case descriptions and overview of the epidemiological situation in Europe with focus on Germany].
Tierarztl Prax Ausg G Grosstiere Nutztiere
December 2024
Laboklin GmbH and Co. KG, Bad Kissingen.
Equine piroplasmosis (EP) is caused by (.) and (.) and is transmitted by hard ticks.
View Article and Find Full Text PDFA 50-year-old question: Can imidocarb chemoprophylaxis ensure seroconversion for babesiosis in cattle under field conditions?
Vet Parasitol
December 2024
Retired researcher at Instituto de Pesquisas Veterinárias Desidério Finamor (IPVDF), Eldorado do Sul, RS 92990-000, Brazil.
Article Synopsis
- Bovine babesiosis, caused by Babesia bovis and Babesia bigemina, significantly impacts livestock and is often treated with imidocarb in areas lacking vaccines.
- The study involved 15 heifers, with 12 receiving imidocarb and all exposed to ticks to evaluate the development of humoral immunity through seroconversion.
- Results showed that after multiple treatments, a majority of the treated heifers did develop antibodies against the parasites, but not all animals seroconverted, highlighting potential limitations in the effectiveness of the chemoprophylaxis approach.
New insights in the diagnosis and treatment of equine piroplasmosis: pitfalls, idiosyncrasies, and myths.
Front Vet Sci
August 2024
Animal Disease Research Unit, Agricultural Research Service, United States Department of Agriculture (USDA), Pullman, WA, United States.
Equine piroplasmosis (EP) is a global tick-borne disease of equids caused by the intraerythrocytic apicomplexan parasites and , and the more recently discovered . These parasites can be transmitted by several tick species, including , , and , but iatrogenic and vertical transmission are also common. Clinical signs of EP include poor performance, fever, icterus, abortions, among others, and peracute or acute forms of infection are associated with high mortality in non-endemic areas.
View Article and Find Full Text PDFA review of Hepatozoonosis caused by in dogs.
J Parasit Dis
September 2024
Present Address: Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
is a type of single-celled organism is spread by ticks and commonly affects dogs. It is responsible for causing one of the most significant parasitic diseases in dogs, called Hepatozoonosis. It is considered one of the most common causes of canine vector-borne diseases because it is closely linked to (the brown dog tick), a species found worldwide.
View Article and Find Full Text PDFThe Establishment of a Novel In Vitro System for Culturing .
Pathogens
July 2024
Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA.
Cytauxzoonosis, a highly fatal tick-borne disease in domestic cats caused by , poses diagnostic and therapeutic challenges due to the inability to culture the parasite in vitro. This study aimed to artificially replicate infection and characterize in vitro replication kinetics. Concanavalin A-activated feline embryonal macrophages (Fcwf-4) were plated at 3-5 × 10 cells/mL and incubated with -positive blood samples from either a (1) chronically infected bobcat (), (2) chronically infected domestic cat, or (3) acutely infected domestic cat with clinical signs of cytauxzoonosis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!