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Low testosterone bioavailability is related to prostate cancer diagnose in patients submitted to prostate biopsy. | LitMetric

AI Article Synopsis

  • The text examines the controversial link between testosterone (T) levels and prostate cancer (PCa) diagnosis, focusing on men with low testosterone.
  • A study analyzed data from 1,000 prostate biopsies, revealing no significant difference in T levels between men with and without PCa, but higher levels of sex hormone-binding globulin (SHBG) in PCa patients.
  • Among men classified as hypogonadal, those with PCa had lower testosterone levels and prostate volumes compared to those without cancer.

Article Abstract

Introduction: Relationship between prostate cancer (PCa) and testosterone (T) is controversial. Conflicting evidence has been published about T levels and development of PCa.

Aim: (1) To determine the relationship between hormone levels and the diagnosis of PCa. (2) To specifically focus on the relationship between PCa and T in men classified as biochemically hypogonadal.

Materials And Methods: Prospective analysis of 1,000 transrectal ultrasound guided prostate biopsies (5 + 5 cores biopsies) between September 2007 and January 2010 in one center. Indication for prostate biopsy was suspicion of PCa on the basis of elevated prostate-specific antigen (PSA) and/or digital rectal examination (DRE). Serum testosterone and sex hormones binding globulin (SHBG) were determined in these patients. Of 557 men, the data were sufficient for further analysis. Age, body mass index (BMI), smoking/drinking habits, PSA, free PSA, PSA density, prostate volume, number of previous biopsies, DRE, and hormone levels were prospectively recorded.

Results: No relationship was found between T and PCa (449 ± 167 ng/dL in PCa versus 437 ± 169 ng/dL in non-PCa). SHBG was significantly higher in patients with PCa (51 ± 27 ng/dL in PCa vs. 44 ± 18 ng/dL in non-PCa). In hypogonadal men, T levels correlated with the PCa (235 ± 95 ng/dL in men with PCa versus 270 ± 58 ng/dL in men without PCa, P = 0.004).

Conclusions: T levels were comparable in men with and without PCa, but SHBG levels were significantly higher in men with PCa. In men with low T, the men with PCa had a lower serum T levels and a lower prostate volume than the men without PCa.

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Source
http://dx.doi.org/10.1007/s00345-011-0741-9DOI Listing

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