AI Article Synopsis
- Engineered bone grafts rely on the interplay of bone-forming cells, structural matrix, and bioactive factors to effectively perform as implants.
- Current advancements focus on creating 3D structures that mimic the natural bone tissue to promote bone formation post-implantation.
- Organ/tissue printing technology facilitates precise 3D arrangements of components, enhancing graft characteristics like porosity and vascularization, and allows for tailored scaffolds with living cells for better bone tissue integration.
Article Abstract
In engineered bone grafts, the combined actions of bone-forming cells, matrix and bioactive stimuli determine the eventual performance of the implant. The current notion is that well-built 3D constructs include the biological elements that recapitulate native bone tissue structure to achieve bone formation once implanted. The relatively new technology of organ/tissue printing now enables the accurate 3D organization of the components that are important for bone formation and also addresses issues, such as graft porosity and vascularization. Bone printing is seen as a great promise, because it combines rapid prototyping technology to produce a scaffold of the desired shape and internal structure with incorporation of multiple living cell types that can form the bone tissue once implanted.
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| http://dx.doi.org/10.1016/j.tibtech.2011.07.001 | DOI Listing |
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