The Fe(II) and α-ketoglutarate-dependent hydroxylase FrbJ was previously demonstrated to utilize FR-900098 synthesizing a second phosphonate FR-33289. Here we assessed its ability to hydroxylate other possible substrates, generating a library of potential antimalarial compounds. Through a series of bioassays and in vitro experiments, we identified two new antimalarials.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091617 | PMC |
| http://dx.doi.org/10.1039/c1cc13597j | DOI Listing |
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