AI Article Synopsis
- Schwannoma is the most common neurogenic tumor originating from the peripheral nerve sheath, with diagnosis requiring tissue analysis and immunohistochemistry due to lack of specific markers or imaging signs.
- A case study highlights a 65-year-old male who had three mass lesions in the chest, with the largest measuring 4.6 × 5 cm, identified through a CT scan.
- After undergoing endoscopic ultrasonography-guided fine needle aspiration, lab results confirmed the lesions as schwannoma by showing positive S-100 staining and negative results for other markers, marking this as the second known case diagnosed using this method.
Article Abstract
Schwannoma is the most common neurogenic tumor that is derived from the peripheral nerve sheath. There are no specific serologic markers or characteristic imaging abnormalities associated with schwannoma. Tissue diagnosis and immunohistochemistry are required to diagnose this lesion. We describe a 65-year-old male with a finding of three mass lesions in the superior and middle mediastinum on computed tomography of the chest. The largest lesion measured 4.6 × 5 cm. The patient subsequently underwent endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA) of the lesion and cytology was consistent with spindle cell neoplasm. Immunohistochemical staining of the cytologic specimen was positive for S-100 and negative for pan-cytokeratin, CD34, CD117, calcitonin, smooth muscle actin and desmin. These findings were consistent with schwannoma. This is the second reported case of a mediastinal schwannoma diagnosed by EUS-FNA.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151001 | PMC |
| http://dx.doi.org/10.1159/000330288 | DOI Listing |
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