A new chiral cationic amphiphile has been synthesized. Sol-gel transcriptions were carried out to control mesoporous silica nanostructures using the organic self-assemblies of this amphiphile as templates. Left-handed coiled mesoporous silica nanoribbons were obtained in the mixture of 1-propanol and 2.5 wt% NH(3) aq. at the ratio of 2:8 and 0 °C. However, right-handed coiled mesoporous silica nanoribbons were prepared in 2.5 wt% NH(3) aq. at 25 °C. The organization of the low-molecular-weight gelators plays an important role in this handedness inversion.
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http://dx.doi.org/10.1088/0957-4484/19/35/355603 | DOI Listing |
Int J Pharm
January 2025
Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.
Nowadays, most of the newly developed active pharmaceutical ingredients (APIs) consist of cohesive particles with a mean particle size of <100μm, a wide particle size distribution (PSD) and a tendency to agglomerate, therefore they are difficult to handle in continuous manufacturing (CM) lines. The current paper focuses on the impact of various glidants on the bulk properties of difficult-to-handle APIs. Three challenging powders were included: two extremely cohesive APIs (acetaminophen micronized (APAPμ) and metoprolol tartrate (MPT)) which previously have shown processing issues during different stages of the continuous direct compression (CDC)-line and a spray dried placebo (SD) powder containing hydroxypropylmethyl cellulose (HPMC), known for its sub-optimal flow with a high specific surface area (SSA) and low density.
View Article and Find Full Text PDFCurr Cancer Drug Targets
January 2025
Department of Clinical Laboratory, Gongli Hospital of Shanghai Pudong New Area, Shanghai, 200135, China.
Background: Lenvatinib is an oral tyrosine kinase inhibitor that selectively inhib-its receptors involved in tumor angiogenesis and tumor growth. It is an emerging first-line treatment agent for hepatocellular carcinoma (HCC). However, there is no intravenous ad-ministration of Lenvatinib.
View Article and Find Full Text PDFNanoscale
January 2025
Department of Biomedical Engineering, Sogang University, Seoul 04107, Korea.
The differentiation of human induced pluripotent stem cells (hiPSCs) into neural progenitor cells (NPCs) is a promising approach for the treatment of neurodegenerative diseases and regenerative medicine. Dual-SMAD inhibition using small molecules has been identified as a key strategy for directing the differentiation of hiPSCs into NPCs by regulating specific cell signaling pathways. However, conventional culture methods are time-consuming and exhibit low differentiation efficiency in neural differentiation.
View Article and Find Full Text PDFJ Pharm Sci
January 2025
Nanotech Laboratory, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) Guwahati, Changsari, Kamrup 781101, Assam, India. Electronic address:
The application of mesoporous silica nanoparticles (MSN) as a drug carrier system got immense attention in the past few years due to their exceptional high drug loading efficiency. However, the process of drug loading is quite challenging compared to other lipid-based drug delivery systems. Hence, the MSNs using different catalysts were synthesized, and their mesoporous material characteristic was confirmed by the type IV adsorption-desorption isotherm using BET analyzer.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Centre for Advanced Laser Manufacturing (CALM), School of Mechanical Engineering, Shandong University of Technology, Zibo 255000, P. R. China.
Developing versatile, scalable, and durable coatings that repel various matters in different service environments is of great importance for engineered materials applications but remains highly challenging. Here, the mesoporous silica microspheres (HMS) fabricated by the hard template method were utilized as micro-nanocontainers to encapsulate the hydrophobic agent of perfluorooctyltriethoxysilane (F13) and the corrosion inhibitor of benzotriazole (BTA), forming the functional microsphere of F-HMS(BTA). Moreover, the synthesized organosilane-modified silica sol adhesive (SMP) and F-HMS(BTA) were further employed as the binder and functional filler to construct a superhydrophobic self-healing coating of SMP@F-HMS(BTA) on various engineering metals through scalable spraying.
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