AI Article Synopsis
- The study investigates the effects of dieckol, extracted from the marine brown alga Ecklonia cava, on the expression of matrix metalloproteinases (MMP-2 and -9) in human fibrosarcoma cells (HT1080).
- Dieckol was found to inhibit both MMP-2 and MMP-9 expression in a dose-dependent manner, reducing cell invasion and changing cell morphology in a 3D culture system.
- The results suggest that dieckol affects the NF-κB signaling pathway to suppress MMP expression, while not significantly impacting the AP-1 pathway or tissue inhibitors of metalloproteinases (TIMPs).
Article Abstract
The matrix metalloproteinase (MMP) family is involved in the breakdown of extracellular matrix in normal physiological processes, as well as in the disease processes such as arthritis and cancer metastasis. In the present study, dieckol was obtained with high yield from marine brown alga Ecklonia cava (EC), and its effect was assessed on the expression of MMP-2 and -9 and morphological changes in human fibrosarcoma cell line (HT1080). Dieckol inhibited the expression of MMP-2 and -9 in a dose-dependent manner and also suppressed the cell invasion and the cytomorphology in 3D culture system on HT1080 cells. Moreover, dieckol may influence nuclear factor kappa B (NF-κB) pathway without obvious influence on activator protein-1 (AP-1) pathway and tissue inhibitor of metalloproteinases (TIMPs). In conclusion, dieckol could significantly suppress MMP-2 and -9 expression and alter cytomorphology of HT1080 cell line via NF-κB pathway.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151525 | PMC |
| http://dx.doi.org/10.1155/2011/140462 | DOI Listing |
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