Mapping of the Faded (fe) Gene to a Region between D10mit191 and D10mit44 on Mouse Chromosome 10.

Lab Anim Res

Department of Medical Genetics, College of Medicine, Hallym University, Chuncheon, Republic of Korea.

Published: March 2011

The faded mouse is a coat color mutant that shows faded coat color and age-related loss of pigmentation. This mutation is transmitted by an autosomal recessive gene with 100% penetrance. In the present study, we carried out linkage analysis of the faded (fe) gene using intra-specific backcross panels. Affected faded mice were carefully confirmed by their faded coat color at about 4 weeks of age. In the intra-specific backcross between faded and CBA mice (n=198), the fe gene was mapped to a region 2.1 cM distal to D10mit191. Therefore, the gene order was defined as follows: centromere-D10mit51 (12.4±2.4 cM)-D10mit191 (2.1±1.0 cM)-fe-D10mit44 (13.3±2.4 cM)-D10mit42 (14.4±2.5 cM). This linkage map of the fe locus will provide a good entry point to isolate the fe gene. Since the faded mouse has pigmentary abnormalities, this mutant may be a useful model for studies of pigmentary abnormalities in humans.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145985PMC
http://dx.doi.org/10.5625/lar.2011.27.1.41DOI Listing

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