A concise stereoselective route to the dysiherbaine tetrahydropyran core was achieved in 9 steps and 39% overall yield. Donohoe's improved tethered aminohydroxylation conditions were employed to concurrently install the amino and alcohol groups and construct the tetrahydropyran ring, which features four contiguous cis-stereocenters.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148768 | PMC |
| http://dx.doi.org/10.1016/j.tetlet.2011.05.106 | DOI Listing |
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