Neoculin, a sweet protein found in the fruit of Curculigo latifolia, has the ability to change sourness into sweetness. Neoculin turns drinking water sweet, indicating that non-acidic compounds may induce the sweetness. We report that ammonium chloride and certain amino acids elicit the intense sweetness of neoculin. Neoculin can thus sweeten amino acid-enriched foods.
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http://dx.doi.org/10.1271/bbb.110081 | DOI Listing |
Arch Anim Nutr
June 2024
The German Federal Institute for Risk Assessment (BfR), Department Safety in the Food Chain, Berlin, Germany.
Hemp ( L.) is an important source of fibre and seed oil and protein. By-products of industrial hemp fibre production, like hemp seeds and cakes, can be used as feed for all animal species as fat and protein source and the whole hemp plant (including stalk and leaves) might be a suitable fibre source for ruminants.
View Article and Find Full Text PDFBioorg Chem
October 2024
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt. Electronic address:
Design and virtual screening of a set of non-acidic 4-methyl-4-phenyl-benzenesulfonate-based aldose reductase 2 inhibitors had been developed followed by chemical synthesis. Based on the results, the synthesized compounds 2, 4a,b, 7a-c, 9a-c, 10a-c, 11b,c and 14a-c inhibited the ALR2 enzymatic activity in a submicromolar range (99.29-417 nM) and among them, the derivatives 2, 9b, 10a and 14b were able to inhibit ALR2 by IC of 160.
View Article and Find Full Text PDFMolecules
April 2024
Analytical and Circular Chemistry (ACC), Institute for Materials Research (IMO-IMOMEC), Hasselt University, Agoralaan, 3590 Diepenbeek, Belgium.
Aligned with the EU Sustainable Development Goals 2030 (EU SDG2030), extensive research is dedicated to enhancing the sustainable use of biomass waste for the extraction of pharmaceutical and nutritional compounds, such as (poly-)phenolic compounds (PC). This study proposes an innovative one-step hydrothermal extraction (HTE) at a high temperature (120 °C), utilizing environmentally friendly acidic natural deep eutectic solvents (NADESs) to replace conventional harmful pre-treatment chemicals and organic solvents. Brewer's spent grain (BSG) and novel malt dust (MD) biomass sources, both obtained from beer production, were characterized and studied for their potential as PC sources.
View Article and Find Full Text PDFJ Med Chem
February 2024
DD Chemistry, Idorsia Pharmaceuticals, Ltd, Hegenheimermattweg 91, CH-4123 Allschwil, Switzerland.
Piperidine is a potent and selective lysophosphatidic acid receptor subtype 1 receptor (LPAR1) antagonist that has shown efficacy in a skin vascular leakage target engagement model in mice. However, compound has very high human plasma protein binding and high clearance in rats, which could significantly hamper its clinical development. Continued lead optimization led to the potent, less protein bound, metabolically stable, and orally active azetidine .
View Article and Find Full Text PDFMater Horiz
October 2023
WestCHEM, School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.
Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) is a material that has become ubiquitous in the field of organic electronics. It is most commonly used as a hole transport layer (HTL) in optoelectronic devices and can be purchased commercially in various formulations with different properties. Whilst it is a most convenient material to work with, there are stability issues associated with PEDOT:PSS that are detrimental to device stability and these are due to the acidic nature of the PSS component.
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