Seven new triterpene glycosides, erylosides R(1) (1), T(1) (3), T(2) (4), T(3) (5), T(4) (6), T(5) (7), and T(6) (8) along with the known formoside (2) were isolated from the sponge Erylus formosus collected along the Caribbean coast of Mexico. Glycoside 1 was determined as a trisaccharide, glycoside 2 as a tetrasaccharide while glycosides 3-8 were hexasaccharide. Their carbohydrate chains were unprecedented and have never been found in oligosaccharides from other biological sources, except Erylus spp. Three carbohydrate chains in the glycosides 3 and 6, 4 and 7, 5 and 8 correspondingly are new. The glycosides 1-5 have penasterol as aglycone while glycosides 6-8 proved to be glycoconjugates of 24-methylene-14-carboxy-lanost-8(9)-en-3β-ol.
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PeerJ
December 2024
Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
The sponge fauna of the Western Mediterranean stands as one of the most studied in the world. Yet sampling new habitats and a poorly studied region like the Balearic Islands highlights once again our limited knowledge of this group of animals. This work focused on demosponges of the order Tetractinellida collected in several research surveys (2016-2021) on a variety of ecosystems of the Balearic Islands, including shallow caves, seamounts and trawl fishing grounds, in a broad depth range (0-725 m).
View Article and Find Full Text PDFAntonie Van Leeuwenhoek
July 2020
Department of Biology, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007, Porto, Portugal.
Humanity faces great challenges, such as the rise of bacterial antibiotic resistance and cancer incidence. Thus, the discovery of novel therapeutics from underexplored environments, such as marine habitats, is fundamental. In this study, twelve strains from the phylum Firmicutes and thirty-four strains from the phylum Proteobacteria, isolated from marine sponges of the Erylus genus, collected in Portuguese waters, were tested for bioactivities and the secondary metabolites were characterised.
View Article and Find Full Text PDFZootaxa
September 2019
Eichenstr. 14, 86507 Oberottmarshausen, Germany. GeoBio-Center LMU München, Richard-Wagner-Str. 10, 80333 München, Germany.
Two new species of Geodiidae from the Emperor Seamounts, North Pacific Ocean are described and compared to congeners. Erylus imperator n. sp.
View Article and Find Full Text PDFFront Microbiol
April 2019
Department of Biology, Faculty of Sciences, University of Porto, Porto, Portugal.
In the beginning of the twenty-first century, humanity faces great challenges regarding diseases and health-related quality of life. A drastic rise in bacterial antibiotic resistance, in the number of cancer patients, in the obesity epidemics and in chronic diseases due to life expectation extension are some of these challenges. The discovery of novel therapeutics is fundamental and it may come from underexplored environments, like marine habitats, and microbial origin.
View Article and Find Full Text PDFCarbohydr Res
September 2017
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Division of the Russian Academy of Science, 690022, Vladivostok, Russia.
Seven new triterpene glycosides, erylosides F (1), V (2), V (3), V (4), W (5), W (6) and W (7), were isolated from a Carribean sponge Erylus goffrilleri collected from the Carribean Sea near the Arrecife-Seco reef (Cuba). Structures of the glycosides were determined using H and C NMR spectroscopy, including 2D NMR procedures (H-H COSY, H-С HMBC, H-С HSQC and NOESY) and HR ESI mass spectrometry. Erylosides 1 and 4 have 14-carboxy-24,25-dimethyllanost-8(9)-en-3β,25-diol as aglycone whereas glycosides 2, 3, 5, 6 and 7 are 14-carboxy-24-acetoxy-24-methyllanost-8(9)-en-3β-ol glycoconjugates.
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