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3D scaffold of hydroxyapatite/β tricalcium phosphate from mussel shells: Synthesis, characterization and cytotoxicity.
Heliyon
January 2025
Department of Cell Biology, Federal University of Paraná, Post box-19031, Zip code -81531-970, Curitiba, PR, Brazil.
Unlabelled: Bone tissue substitutes are increasing in importance. Hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) act as a cell matrix and improve its mechanical properties. One of their raw materials is marine-origin by-products.
View Article and Find Full Text PDFMixed histiocytic sarcoma in a Bernese Mountain Dog.
J Vet Diagn Invest
January 2025
Veterinary Diagnostic Laboratory-Microbiology, Immunology, Pathology, Colorado State University, Fort Collins, CO, USA.
An 8-y-old, spayed female Bernese Mountain Dog was presented to a referral center for evaluation of right thoracic limb lameness and previously suspected Evans syndrome that had been poorly responsive to immunosuppressive therapy. Based on review of examination findings and laboratory data, Evans syndrome was deemed unlikely and hemophagocytic histiocytic sarcoma (HHS) was strongly suspected. On blood smear evaluation, atypical, histiocytic cells were noted, some of which exhibited siderophagia.
View Article and Find Full Text PDFExploring the impact of sEH inhibition on intestinal cell differentiation and Colon Cancer: Insights from TPPU treatment.
Toxicol Appl Pharmacol
November 2024
Department of Histology and Embryology, Faculty of Medicine and Dentistry, Palacky University, 779 00 Olomouc, Czech Republic. Electronic address:
Inhibition of soluble epoxide hydrolase (sEH) appears to be promising for the treatment of many diseases. Studies have focused on the beneficial effects of epoxyeicosatrienoic acids (EETs), which are sEH substrates. However, our recent studies have shown that the sEH activity is crucial for the proper intestinal cell differentiation.
View Article and Find Full Text PDFA novel investigation of NANOG and POU5F1 associations in the pluripotent characterization of ES-like and epiblast cells.
Sci Rep
October 2024
Faculty of Biotechnology, Amol University of Special Modern Technologies, P.O.Box: 46168-49767, Amol, Iran.
The transcription factors NANOG and POU5F1 (OCT4) play crucial roles in maintaining pluripotency in embryonic stem (ES) cells. While their functions have been well-studied, the specific interactions between NANOG and POU5F1 and their combined effects on pluripotency in ES-like and Epiblast cells remain less understood. Understanding these associations is vital for refining pluripotent stem cell characterization and advancing regenerative medicine.
View Article and Find Full Text PDFα-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson's disease.
Mol Neurodegener
October 2024
Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Article Synopsis
- The study investigates how pathological aggregation of α-synuclein (aSYN) contributes to neuron dysfunction in Parkinson's disease, focusing on mitochondrial impact.
- Researchers injected pre-formed aSYN fibrils into specific mouse brain regions and employed various techniques to analyze the effects 12 weeks later.
- Results showed that aSYN accumulation led to neuronal loss, reduced mitochondrial function, increased oxidative stress, and compromised energy production in dopaminergic neurons, suggesting mitochondrial disruption as an early event in the disease process.
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