AI Article Synopsis
- MAVS protein is essential for creating an antiviral signaling complex on mitochondrial membranes.
- Virus infection causes MAVS to undergo a conformational change.
- This change leads to the formation of self-aggregates that effectively trigger antiviral signaling.
Article Abstract
The MAVS protein plays a critical role in the assembly of an antiviral signaling complex on mitochondrial membranes. Hou et al. (2011) now report that virus infection induces a conformational change in MAVS, leading to the prion-like formation of functional self-aggregates that provide a sensitive trigger for antiviral signaling.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272580 | PMC |
| http://dx.doi.org/10.1016/j.cell.2011.07.018 | DOI Listing |
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