AI Article Synopsis
- Asthma is influenced by both genetic and environmental factors, and a study was conducted on 938 Japanese pediatric asthma patients and 2,376 controls to investigate this.
- Strong associations were identified with specific genetic variations (SNPs) between the HLA-DPA1 and HLA-DPB1 genes, particularly SNP rs987870, which was linked to pediatric asthma in three different populations.
- The study found strong links between certain HLA-DP alleles (DPA1*0201 and DPB1*0901) and pediatric asthma, suggesting that these genetic variants increase the risk of developing asthma in Asian children.
Article Abstract
Asthma is a complex phenotype influenced by genetic and environmental factors. We conducted a genome-wide association study (GWAS) with 938 Japanese pediatric asthma patients and 2,376 controls. Single-nucleotide polymorphisms (SNPs) showing strong associations (P<1×10(-8)) in GWAS were further genotyped in an independent Japanese samples (818 cases and 1,032 controls) and in Korean samples (835 cases and 421 controls). SNP rs987870, located between HLA-DPA1 and HLA-DPB1, was consistently associated with pediatric asthma in 3 independent populations (P(combined) = 2.3×10(-10), odds ratio [OR] = 1.40). HLA-DP allele analysis showed that DPA1*0201 and DPB1*0901, which were in strong linkage disequilibrium, were strongly associated with pediatric asthma (DPA1*0201: P = 5.5×10(-10), OR = 1.52, and DPB1*0901: P = 2.0×10(-7), OR = 1.49). Our findings show that genetic variants in the HLA-DP locus are associated with the risk of pediatric asthma in Asian populations.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140987 | PMC |
| http://dx.doi.org/10.1371/journal.pgen.1002170 | DOI Listing |
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