AI Article Synopsis
- - Neutral amino acid transporters from the SLC6 family are found in the kidney and small intestine, where they help absorb amino acids into the body.
- - The review highlights the importance of these transporters' association with partner proteins like Tmem27 and ACE2, particularly focusing on B0AT1 and B0AT3 in a tissue-specific context.
- - It also discusses how these associations contribute to functional units for transporting sodium (Na+) or amino acids, and notes their relevance to Hartnup disorder, where certain mutations affect interactions with partner proteins.
Article Abstract
Neutral amino acid transporters of the SLC6 family are expressed at the apical membrane of kidney and/or small intestine, where they (re-)absorb amino acids into the body. In this review we present the results concerning the dependence of their apical expression with their association to partner proteins. We will in particular focus on the situation of B0AT1 and B0AT3, that associate with members of the renin-angiotensin system (RAS), namely Tmem27 and angiotensin-converting enzyme 2 (ACE2), in a tissue specific manner. The role of this association in relation to the formation of a functional unit related to Na+ or amino acid transport will be assessed. We will conclude with some remarks concerning the relevance of this association to Hartnup disorder, where some mutations have been shown to differentially interact with the partner proteins.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.4161/chan.5.5.16470 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!