Impaired chemosensitivity is an important element of the pathogenesis and the course of various cardiovascular diseases. Our paper presents the assessment of the sensitivity of the central (located on the ventrolateral medullary surface, sensitive to hypercapnea and acidosis) and peripheral (located in the carotid and aortic bodies, sensitive to hypoxia) chemoreceptors, pointing out a physiological and clinical aspects of their application.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Acute effects of esketamine on hypoxic ventilatory response, haemodynamics, and brain function in healthy volunteers.
Br J Anaesth
November 2024
Anesthesia & Pain Research Unit, Leiden University Medical Center, Leiden, The Netherlands.
Background: The acute hypoxic ventilatory response is a critical chemoreflex originating at the carotid bodies. This study investigates the impact of low-dose i.v.
View Article and Find Full Text PDFEffect of endothelin-1 on the blood pressure response to acute hypoxia and hyperoxia in healthy young men.
Physiol Rep
September 2024
Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA.
Endothelin-1 (ET-1) and its receptors are linked to increases in sensitivity of the chemoreceptors to hypoxic stress and the development of hypertension in preclinical models. We hypothesized ET receptor antagonism would lower resting blood pressure (BP) as well as the acute BP response to chemoreflex stress. Twenty-four men (31 ± 5 years, 26 ± 3 kg/m) completed two study visits (control, bosentan).
View Article and Find Full Text PDFRole of the peripheral chemoreceptors in cardiovascular and metabolic control in type 2 diabetes.
J Physiol
October 2024
Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO, USA.
Preclinical work supports a role for the peripheral chemoreceptors in the progression of cardiovascular and metabolic pathologies. In the present study, we examined peripheral chemosensitivity in adults with type 2 diabetes (T2D) and the contribution of the peripheral chemoreceptors to resting cardiovascular and metabolic control. We hypothesized that: (1) adults with T2D exhibit exaggerated peripheral chemoreflex sensitivity; (2) the peripheral chemoreceptors contribute to cardiovascular dysfunction in T2D; and (3) attenuation of peripheral chemoreceptor activity improves glucose tolerance in T2D.
View Article and Find Full Text PDFNucleus of the solitary tract neuronal degeneration and impaired hypoxia response in a model of Parkinson's disease.
Exp Neurol
October 2024
Department of Pharmacology, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, SP, 05508 Sao Paulo, SP, Brazil. Electronic address:
Parkinson's disease (PD) involves the degeneration of dopaminergic neurons in the substantia nigra (SNpc) and manifests with both classic and non-classic motor symptoms, including respiratory failure. Our study aims to investigate the involvement of the commissural and intermediate nucleus of the solitary tract (cNTS and iNTS) in the attenuated respiratory response to hypoxia in PD. Using a PD rat model induced by bilateral injection of 6-hydroxydopamine (6-OHDA) into the striatum of male Wistar rats, we explored potential alterations in the population of Phox2b neurons or hypoxia-activated neurons in the NTS projecting to the retrotrapezoid nucleus (RTN).
View Article and Find Full Text PDFGefapixant as a P2X3 receptor antagonist treatment for obstructive sleep apnea: a randomized controlled trial.
J Clin Sleep Med
December 2024
Merck & Co., Inc., Rahway, New Jersey.
Study Objectives: Obstructive sleep apnea (OSA) is a highly prevalent disorder with serious health consequences but limited therapeutic options. For a subset of those with OSA, a key underlying mechanism is hypersensitive chemoreflex control of breathing. There is no approved therapy that targets this endotypic trait.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!