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In all aspects of orthopaedic surgery, restoring native patient anatomy has shown improved outcomes in comparison to nonanatomic reconstructions. Particular attention has been paid to the hip capsule, as the complex of the iliofemoral, pubofemoral, and ischiofemoral ligaments, as well as the zona orbicularis and iliocapsularis, all play an essential role in hip stability, mechanics, and maintenance of intra-articular pressures. An anatomic approach toward hip arthroscopy also includes labral repair or reconstruction with preservation of the chondrolabral junction and cam resection.
View Article and Find Full Text PDFH4K20me3-Mediated Repression of Inflammatory Genes Is a Characteristic and Targetable Vulnerability of Persister Cancer Cells.
Cancer Res
January 2025
Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Anticancer therapies can induce cellular senescence or drug-tolerant persistence, two types of proliferative arrest that differ in their stability. While senescence is highly stable, persister cells efficiently resume proliferation upon therapy termination, resulting in tumor relapse. Here, we used an ATP-competitive mTOR inhibitor to induce and characterize persistence in human cancer cells of various origins.
View Article and Find Full Text PDFHarnessing the power of patient engagement in evaluating a novel brace for knee osteoarthritis: a co-produced commentary.
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McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, AB, Canada.
Introduction: Patient oriented research (POR) invites patients to partner with researchers, clinicians, and other stakeholders, incorporating diverse perspectives to generate scientific evidence meaningful to all parties involved. We adopted a POR approach for this study evaluating the feasibility of conducting a randomized control trial of a novel tri-compartment offloader brace for knee osteoarthritis. We involved patients as partners to enhance study design, implementation and interpretation of key outcomes.
View Article and Find Full Text PDFBispecific Antibodies as Bridging to BCMA CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma.
Blood Cancer Discov
January 2025
Department of Hematology, Hemostaseology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany.
Establishing a strategy for sequencing of T cell-redirecting therapies for relapsed/refractory multiple myeloma (RRMM) is a pressing clinical need. We longitudinally tracked the clinical and immunologic impact of bispecific T cell-engaging antibodies (BsAb) as bridging therapy (BT) to subsequent B-cell maturation antigen-directed chimeric antigen receptor T (CAR-T) cell therapies in 52 patients with RRMM. BsAbs were a potent and safe option for BT, achieving the highest overall response rate (100%) to BT compared with chemotherapy, anti-CD38, or anti-SLAMF7 antibody-based regimens (46%).
View Article and Find Full Text PDFMaking in vitro conditions more reflective of in vivo conditions for research on the teleost gastrointestinal tract.
J Exp Biol
October 2024
Department of Zoology, University of British Columbia, 6270 University Blvd, Vancouver, BC, V6T1Z4, Canada.
Article Synopsis
- Most fish gastrointestinal research has been conducted in unrealistic lab conditions that don't accurately reflect the complex environments found in live fish, including variations in ionic conditions, pH, and oxygen levels.
- The gut microbiome, crucial for normal gut function, is hard to replicate in lab settings, complicating research further.
- To improve research accuracy, it's important to consider gut compartment chemistry, maintain microbiome diversity, and develop solutions that mimic live conditions, potentially by using advanced technologies like 'gut-on-chip' devices from mammalian studies.
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