Lancerodiol-p-hydroxybenzoate was isolated from the leaves of Ferula sinaica L. (Apiaceae) as light needle crystals. This work reports for the first time the molecular structure and relative configuration of compound 1, established by X-ray analysis.
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http://dx.doi.org/10.4103/0974-8490.62950 | DOI Listing |
Methods Mol Biol
January 2025
Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.
The human genome is composed of distinct genomic regions that are susceptible to various types of somatic mutations. Among these, Short Tandem Repeats (STRs) stand out as the most mutable genetic elements. STRs are short repetitive polymorphic sequences, predominantly situated within noncoding sectors of the genome.
View Article and Find Full Text PDFMethods Mol Biol
January 2025
Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
The HOX and PBX genes encode transcription factors that have key roles in development and cancer, both independently and as a heterodimer within a complex of proteins that recognizes specific sequences in DNA and can both activate and repress transcription of target genes. Due to functional redundancy amongst HOX proteins, knock down or knock out studies of individual genes often do not result in an altered phenotype. An alternative approach is to target the interaction between HOX and PBX proteins, which is dependent on a conserved hexapeptide region within HOX.
View Article and Find Full Text PDFJ Virol
December 2024
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.
Unlabelled: Flavivirus envelope (E) and precursor M (prM) proteins, when ectopically expressed, assemble into empty, virus-like particles (VLPs). Cleavage of prM to M and loss of the pr fragment converts the VLPs from immature to mature particles, mimicking a similar maturation of authentic virions. Most of the VLPs obtained by prM-E expression are smaller than virions; early, low-resolution cryo-EM studies suggested a simple, 60-subunit, icosahedral organization.
View Article and Find Full Text PDFDalton Trans
January 2025
Laboratory for Molecular & Functional Design, Department of Engineering, Nara Women's University, Nara 630-8506, Japan.
Rational molecular design afforded fluorescent Cd sensors based on bisquinoline derivatives. Introduction of three methoxy groups at the 5,6,7-positions of the quinoline rings of BQDMEN (,'-bis(2-quinolylmethyl)-,'-dimethylethylenediamine) resulted in the reversal of metal ion selectivity in fluorescence enhancement from zinc to cadmium. Introduction of bulky alkyl groups and an ,-bis(2-quinolylmethyl)amine structure, as well as replacement of one of the two tertiary amine binding sites with an oxygen atom and the use of a 1,2-phenylene backbone significantly improved the Cd specificity.
View Article and Find Full Text PDFChem Commun (Camb)
January 2025
Center for High Pressure Science and Technology Advanced Research (HPSTAR), Shanghai, China.
Functional materials, possessing specific properties and performing particular functions beyond their mechanical or structural roles, are the foundation of modern matter science including energy, environment, and quantum sciences. The atomic and electronic structures of these materials can be significantly altered by external stimuli such as pressure. High-pressure techniques have been extensively utilized to deepen our understanding of structure-property relationships of materials, while also enabling emergent or enhanced properties.
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